Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed "Let food be thy medicine and medicine be thy food." This advice parallels the common American saying, "You are what you eat," and is supported by a National Institute of Health recommendation to consume as many as eight servings of fruits and vegetables daily to prevent common diseases.One of the most therapeutically significant components found in food is the polyphenol resveratrol. First described in Ayurvedic medicine 5000 years ago as a cardiotonic, resveratrol is found in several fruits and vegetables including grapes, peanuts, cranberries, blueberries, mulberries, and jackfruit. A favorite and rich source of resveratrol is red wine. Resveratrol in Health and Disease draws on the expertise of an international panel, representing a cross-section of nutrition-related disciplines, to examine the effects and properties of this legendary nutrient. It explores research that examines a wide range of purported healing and preventive powers:Cardioprotective agent Antitumor agent Angiogenesis inhibitor Antioxidant Radioprotective agent Phytoestrogen source Antifungal and antibacterial agent Neuroprotective agent Modulator of immune system Anti-inflammatory agentReviewing recent literature, these pages explore the pharmacokinetics and metabolism of resveratrol, consider its molecular targets, and look at its role in modulating gene expression, as well as its impact on the mechanism of apoptosis and cell signaling pathways.Considering the prohibitive costs of modern medicine, the need for readily available products that are safe and efficacious is critical. Consequently, Resveratrol in Health and Disease may well find its own place in history by providing scientists, clinicians, herbalogists, naturopaths, and those they serve, with the first c
Resveratrol: A Polyphenol for All Seasons: Shishir Shishodia and Bharat B. AggarwalSources and Chemistry of Resveratrol: Navindra P. Seeram, Vishal V. Kulkarni, and Subhash PadhyeResveratrol as an Antioxidant: Catalina Alarcón de la Lastra, Isabel Villegas, and Antonio Ramón MartínResveratrol as an Antiproliferative Agent for Cancer: Paola Signorelli and Riccardo GhidoniMechanism of Apoptosis by Resveratrol: Shazib Pervaiz and Andrea Lisa HolmeResveratrol as Inhibitor of Cell Survival Signal Transduction: Simone Fulda and Klaus-Michael DebatinResveratrol as Inhibitor of Cell Cycle Progression: Jen-Kun LinMolecular Targets of Resveratrol: Implications to Health and Disease Prevention: Catherine A. O'Brian and Feng ChuResveratrol as an Angiogenesis Inhibitor: Ebba Bråkenhielm, Renhai Cao, and Yihai CaoResveratrol Modulation of Gene Expression: The Role of Transcription Factors: Fulvio Della Ragione, Valeria Cucciolla, Adriana Borriello, and Vincenzo ZappiaModulation of Gene Expression by Resveratrol: Bhagavathi A. Narayanan and Narayanan K. NarayananResveratrol and Prostaglandin Biosynthesis: Lawrence M. Szewczuk and Trevor M. PenningResveratrol as an Inhibitor of Carcinogenesis : John M. PezzutoResveratrol as an Antitumor Agent In Vivo: Francis RaulResveratrol as a Sensitizer to Apoptosis-Inducing Stimuli: Ali R. Jazirehi and Benjamin BonavidaResveratrol as a Radio-Protective Agent: Yogeshwer Shukla, Shannon Reagan-Shaw, and Nihal AhmadResveratrol as a Phytoestrogen: Barry D. Gehm and Anait S. LevensonResveratrol as an Antibacterial Agent: Gail B. MahadyResveratrol as an Antifungal Agent: Marielle Adrian and Philippe JeandetProtective Effects of Resveratrol in Age-Related Neurodegenerative Diseases and Gene Regulatory Action: Sofiyan Saleem, Abdullah Shafique Ahmad, and Sylvain DoréProtective Effects of Resveratrol against Ischemia-Reperfusion: Dipak K. DasResveratrol as Cardioprotect