Receptor Binding in Drug Research

Inbunden, Engelska, 1986

Av Robert A. O'Brien, Robert a. O'Brien, A. O'brien, A. O'Brien

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This book describes the applications of receptor techniques in many different areas in addition to conventional drug and neurotransmitter binding sites. It reviews humoral modulators such as a leukotrienes, interferon, platelet-derived growth factor, and novel endogenous ligands.

Produktinformation

Utgivningsdatum1986-06-25
Mått178 x 254 x 34 mm
Vikt1 170 g
FormatInbunden
SpråkEngelska
SerieClinical Pharmacology
Antal sidor544
FörlagTaylor & Francis Inc
ISBN9780824775483

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Part I: Analysis and Interpretation of Receptor Screening Data 1. Receptor Binding Methodology and Analysis 2. Computer Analysis of Binding Data James Part II: Receptor Screening Applied to Specific Therapeutic Areas 3. Benzodiazepines and Nonbenzodiazepines 4. Enhancers of Benzodiazepine Binding 5. Convulsant and Anticonvulsant Drug Receptor Binding 6. Neuroleptic Receptor Binding in Drug Research 7. Receptor Binding and Atypical Antidepressant Drug Discovery 8. Central Recognition Sites for Psychomotor Stimulants: Methylphenidate and Amphetamine 9. Opiate Receptor Binding in Drug Research Part III: Receptor Interactions with Implications in Multiple Therapeutic Areas 10. Molecular Heterogeneity of Leukotriene Receptors 11. Purinergic Receptors in Mammalian Tissue 12. New Routine Methodology to Study Steroid Hormone Binding Sites in Heterogeneous Tissues 13. pplication of Ligand Binding to the Development of New Calcium Antagonists and Activators 14. Muscarinic Cholinergic Receptor Binding Part IV: Receptor Applications to Peptides, Growth Factors, and Endogenous Ligands 15. Interferon Receptors: Progress and Prospects 16. The Platelet-Derived Growth Factor Receptor 17. Receptor Screening Assays for Insulin and Other Growth Factors 18. Cholecystokinin Receptor Binding: Its Use in Drug Research and Development 19. Using Radioreceptor Binding Assays to Identify Endogenous Ligands Part V: In Vivo and In Vitro Receptor Methodologies for Use in Drug Discovery and Characterization 20. In Vivo Receptor Modifications as a Measure of Antidepressant Potential 21. Antidepressant Interactions with Neurotransmitter Receptors in Vitro: Prediction of Potential Side Effects 22. Altered Responsiveness of the Noradrenergic-Coupled Adenylate Cyclase System in Brain 23. Quantitative Autoradiography in Drug Research: Tricyclic Antidepressants 24. Characterization of Agonist and Antagonist Interactions at the Benzodiazepine Receptor 25. Receptor Binding Assays for Muscarinic Cholinergic Agonists