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This is a study based on the proceedings of a workshop concerned with extracellular virulence factors of mucoid strains of Pseudomonas aeruginosa in relation to Cystic Fibrosis. It is intended to further the understanding of mucoid P. aeruginosa infections and to provide benefit to those who need it most - the children and adults suffering from CF. It focuses on alginate as an extracellular virulence factor of P.aeruginosa in CF pulmonary infections and presents advances in the biochemistry and molecular genetics of alginate biosynthesis and the basic defect in CF and isolation of the gene. The non-mucoid to mucoid transformation "in vitro" and "in vivo" are discussed in relation to host responses to alginate. The structure, properties, and biosynthesis including genetics of alginate are dealt with in detail and related to its chemical physical and biological properties.
1 Introduction: Pseudomonas aeruginosa, an opportunist pathogen.- 2 Clinical aspects of mucoid Pseudomonas aeruginosa infections.- 3 The structure and properties of alginate.- 4 Characteristics of mucoid Pseudomonas aeruginosa in vitro and in vivo.- 5 The microcolony mode of growth in vivo — an ecological perspective.- 6 Adherence and the role of alginate.- 7 Immunology of alginate and other surface antigens in mucoid and non-mucoid Pseudomonas aeruginosa.- 8 The contribution of Pseudomonas aeruginosa alginate to evasion of host defence.- 9 Interactions of alginate with exoenzymes.- 10 Biosynthesis of alginate.- 11 Genetics of alginate biosynthesis in Pseudomonas aeruginosa.- 12 Future prospects.
...This excellent book presents the case for alginate as one of the major determinants to P. aeruginosa virulence...The contributors are all renowned experts in the field and the book is thoroughly recommended. Society for General Microbiology
