Primary Biliary Cirrhosis

From Pathogenesis to Clinical Treatment

Häftad, Engelska, 2012

AvKeith D. Lindor,E. Jenny Heathcote,Raoul E. Poupon

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The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer.

Produktinformation

Utgivningsdatum2012-10-09
Mått155 x 235 x 11 mm
Vikt306 g
FormatHäftad
SpråkEngelska
Antal sidor176
FörlagSpringer
ISBN9789401060479

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Klinisk medicin och internmedicin inom Medicin

Section I: Natural History and Pathogenesis.- 1 Natural history and demography of primary biliary cirrhosis.- 2 Immune basis for PBC.- 3 Isolation and cloning of antimitochondrial antibodies.- 4 Significance of antimitochondrial antibody profiles in primary biliary cirrhosis.- 5 Chloride/bicarbonate exchange in PBC: a clue for pathogenesis?.- 6 Molecular considerations of primary biliary cirrhosis.- 7 Animal models of primary biliary cirrhosis.- 8 Fibrogenesis in PBC.- 9 Natural history models of primary biliary cirrhosis.- Section II: Management of Primary Biliary Cirrhosis.- 10 Portal hypertension in patients with primary biliary cirrhosis.- 11 Management of primary biliary cirrhosis: osteoporosis.- 12 Fatigue in the primary biliary cirrhosis patient.- 13 The pruritus of cholestasis: behavioral studies shed light on its pathogenesis.- 14 Old and new immunosuppressant drugs: mechanisms and potential value.- 15 Methotrexate and colchicine in the treatment of primary biliary cirrhosis.- 16 Corticosteroids in PBC.- 17 Ursodeoxycholic acid treatment of primary biliary cirrhosis: potential mechanisms of action.- 18 Ursodiol and combination therapy.- 19 Primary biliary cirrhosis transplantation and recurrent disease.- 20 New clinical trials in primary biliary cirrhosis: design and endpoints.