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The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer.
Section I: Natural History and Pathogenesis.- 1 Natural history and demography of primary biliary cirrhosis.- 2 Immune basis for PBC.- 3 Isolation and cloning of antimitochondrial antibodies.- 4 Significance of antimitochondrial antibody profiles in primary biliary cirrhosis.- 5 Chloride/bicarbonate exchange in PBC: a clue for pathogenesis?.- 6 Molecular considerations of primary biliary cirrhosis.- 7 Animal models of primary biliary cirrhosis.- 8 Fibrogenesis in PBC.- 9 Natural history models of primary biliary cirrhosis.- Section II: Management of Primary Biliary Cirrhosis.- 10 Portal hypertension in patients with primary biliary cirrhosis.- 11 Management of primary biliary cirrhosis: osteoporosis.- 12 Fatigue in the primary biliary cirrhosis patient.- 13 The pruritus of cholestasis: behavioral studies shed light on its pathogenesis.- 14 Old and new immunosuppressant drugs: mechanisms and potential value.- 15 Methotrexate and colchicine in the treatment of primary biliary cirrhosis.- 16 Corticosteroids in PBC.- 17 Ursodeoxycholic acid treatment of primary biliary cirrhosis: potential mechanisms of action.- 18 Ursodiol and combination therapy.- 19 Primary biliary cirrhosis transplantation and recurrent disease.- 20 New clinical trials in primary biliary cirrhosis: design and endpoints.
Nicholas J. Talley, Kenneth R. DeVault, Michael B. Wallace, Bashar A. Aqel, Keith D. Lindor, Kenneth R DeVault, Michael B Wallace, Bashar A Aqel, Keith D Lindor
Keith D. Lindor, Hugo E. Vargas, USA) Lindor, Keith D. (Mayo Clinic College of Medicine, Rochester, MN, USA) Vargas, Hugo E. (Mayo Clinic College of Medicine, Phoenix, AZ, Keith D Lindor, Hugo E Vargas