Pediatric and Adult Celiac Disease

Dr. Corazza is Emeritus Professor of Internal Medicine at the University of Pavia, Italy. He got a specialization in Internal Medicine and Gastroenterology, and he spent a training period at the University of Leeds, focusing on intestinal diseases and malabsorption, under the direction of Professor Monty S. Losowsky (1978-1980). His research activity has mainly focused on celiac disease, other food intolerances, and inflammatory bowel disease. He has won multiple scientific awards, and he has been Editor of several Internal Medicine and Medical Therapeutics volumes and textbooks. He has served in the Scientific Board of the Italian Society of Gastroenterology, and, at present, he is an honorary member of the same Society. He has also served in the Executive Council of the Italian Society of Internal Medicine, and he has been elected as President in the years 2013-2015. Currently, he is Honorary President of the same Society. Moreover, he has been President of the Scientific Board of the Italian Celiac Association (AIC), and he is still a member of the Scientific Board. He was named a member of the Select Committee of Selection of Scientific Programs of the Ministry of University and the Group of Experts of Rating Research Products - Medical Sciences Area (GEV06). Dr. Troncone is Full Professor and Head of the Department of Pediatrics at the University Federico II in Naples, Italy. His specialty is Pediatrics, but he has also been trained in mucosal immunology (1985-1987) at the University of Edinburgh under the direction of Professor Anne Ferguson. Celiac disease (CD) represents his main research field and most of his scientific production is focused on this area. He contributed, among others, to research areas such as mucosal cytokines, tissue transglutaminase (tTG) antibodies and the relationship of CD with autoimmune diseases. In the 5th framework he has been coordinator of the subproject Pathogenesis within the EU-Cluster on Celiac Disease (Coeliac-EU/cluster N°QLRT-1999-00037). Dr. Marco Vincenzo Lenti is Associate Professor of Internal Medicine at the University of Pavia and Gastroenterology Consultant at the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. He has spent part of his training as a research fellow at the Gastroenterology Clinic of St. James’s Hospital, University of Leeds, UK. He has always been interested in clinical and translational research in the field of internal medicine and gastroenterology. He has led, coordinated, and taken part to several national and international mono- or multicenter studies regarding celiac disease, autoimmune gastritis, inflammatory bowel disease, and clinical complexity, which are the main fields of his research activity. He is currently a member of the Scientific Board of the Italian Society of Gastroenterology. He has won, as principal investigator, several competitive national and international grants, including one supported by the United European Gastroenterology for the writing of international guidelines on malabsorption. Dr. Marco Silano is currently Research Director, Director of the Department of Cardiovascular and Endocrine-metabolic Diseases and Aging, and Acting Director of the National center of Rare Diseases, Istituto Superiore di Sanità, Rome, Italy. He graduated from the Catholic University of the Sacred Heart in Rome and specialized in Pediatrics at the University of Milan. He has been serving as Coordinator of the Scientific Board of the Italian Celiac Patients Association (AIC). He is Member of the National Committee for Food Safety and Nutrition and of the Working Group for Food Security at the Italian Ministry of Health.

• 1. Introduction and definitions2. The dynamic epidemiology of coeliac disease3. Gluten, gliadin, and toxic epitopes4. Genetic predisposition5. Relevance of environmental cofactors6. Immunological mechanisms of lesions7. Coeliac disease in paediatric patients8. Coeliac disease in adult patients9. Serology and screening in risk groups10. Role of intestinal biopsy in childhood and adult coeliac disease11. Potential coeliac disease12. Chronic enteropathies with negative coeliac serology in adults13. Gluten free diet, assessment of its adherence, and quality of life14. Medical treatments and follow-up for clinical conditions associated to coeliac disease15. Refractory coeliac disease and lymphomagenesis16. Infectious and other oncological complications17. Herpetiformis dermatitis 18: Non-coeliac gluten-related disorder19. Normative framework and public health interventions for the protection of coeliac disease patients20. The role of patient associations21. Emerging putative therapeutic targets in coeliac disease22. Future directions

*4 stars* "...provides a comprehensive, timely, and critical review of celiac disease and its associated complications and comorbidities.... [C]ontains well-structured chapters with numerous tables, figures, images, algorithms, and decision trees which enhance the reading experience…. [A] clear, up-to-date summary of pediatric and adult celiac disease for all professionals and scientists… with a deliberately clinical approach. One standout element is its goal of intentionally writing for a broad audience of professionals and scientists. The writing is consistently clear and well-referenced, [and] the reading experience is enhanced by colorful figures, comprehensive tables, algorithms, and decision trees.... This is a very well written, comprehensive, up-to-date resource which will be useful to the intended broad audience by striking a balance between breadth and depth in its coverage of celiac disease." --©Doody’s Review Service, 2024, Pamela M. Williams, MD (Uniformed Services University of the Health Sciences)