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265 sidor
2008

In 1920s, Otto Warburg described the phenomenon of aerobic glycolysis, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburgs hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Författare: Guido Kroemer, Dominik Mumberg, Kector Keun, Bjrn Riefke, Thomas Steger-Hartmann
Illustratör: 7 schwarz-weiße Tabellen 37 schwarz-weiße und 18 farbige Abbildungen
Format: Inbunden
ISBN: 9783540794776
Språk: Engelska
Antal sidor: 265
Utgivningsdatum: 2008-08-20
Förlag: Springer-Verlag Berlin and Heidelberg GmbH & Co. K