Del i serien Woodhead Publishing Series in Biomedicine

NMR Metabolomics in Cancer Research

Inbunden, Engelska, 2012

3 019 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt för medlemmar vid köp för minst 249 kr.

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.

Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics
Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications
Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Produktinformation

Utgivningsdatum2012-12-17
Mått156 x 234 x undefined mm
Vikt810 g
FormatInbunden
SpråkEngelska
SerieWoodhead Publishing Series in Biomedicine
Antal sidor446
FörlagElsevier Science
ISBN9781907568848

Tillhör följande kategorier

Onkologi inom Medicin
Medicinsk bildbehandling inom Medicin

Dr Miroslava Cuperlovic-Culf is a Research Officer at the National Research Council of Canada Institute for Information Technology, an Adjunct Professor of Chemistry at Mount Allison University and an Adjunct Researcher at the Atlantic Cancer Research Institute. She has a range of publications and patents resulting from research in NMR spectral analysis and modelling, bioinformatics data analysis and computational biology for cellular pathway modelling, as applied to cancer research.

List of figuresList of tablesAbbreviationsAbout the authorChapter 1: IntroductionAbstract:1.1 Possibilities of NMR metabolomics in cancer researchChapter 2: Biology – cancer metabolic phenotypeAbstract:2.1 Cancer metabolic phenotype2.2 Drugs aimed at cancer metabolic phenotypeChapter 3: Experimental methodologyAbstract:3.1 Fundamentals of NMR spectroscopy3.2 1D NMR in mixture analysis3.3 Multidimensional NMR in metabolomics3.4 Arrayed NMR experiments3.5 Isotope labeling for NMR analysis3.6 Diagnostic magnetic resonance tools based on cancer metabolic phenotype and cancer-induced metabolic changesChapter 4: Metabolomics NMR data preprocessing – analysis of individual spectrumAbstract:4.1 NMR spectrum preprocessing4.2 Qualitative metabolomics4.3 STOCSY4.4 Quantitative metabolomics4.5 Novel metabolite structure analysisChapter 5: Metabolomics data analysis – processing and analysis of a datasetAbstract:5.1 Normalization and scaling5.2 Biases and confounders in metabolomics5.3 Data analysis5.4 Data integration – polyomics analysisChapter 6: Dynamic metabolic profiling and metabolite network and pathways modelingAbstract:6.1 Dynamic metabolic data analysis6.2 Computational models of metabolic networksChapter 7: Biomarker discoveryAbstract:7.1 Feature (biomarkers) selection7.2 Validation of results in supervised analysisChapter 8: NMR metabolomics application by cancer typeAbstract:8.1 Breast cancer8.2 Brain cancers8.3 Lung cancer metabolomics analysis and results8.4 Metabolomics analysis of biofluids in cancer researchChapter 9: PerspectivesIndex