Next-Generation Approaches in Malaria Research

Nyhet

Molecular Strategies and Translational Insights

Inbunden, Engelska, 2026

2 149 kr

Kommande

This book presents the molecular basis, host–parasite interactions, and translational advances in malaria research, with a specific focus on Plasmodium falciparum. It examines parasite pathogenesis, including life cycle progression, erythrocyte invasion, cytoadherence, and immune evasion mechanisms that drive clinical disease. The book explores advances in parasite genomics and functional genomics, highlighting genome engineering approaches such as CRISPR-based editing for gene function analysis and drug target validation. It also covers contemporary malaria diagnostic strategies, including molecular and point-of-care platforms designed for sensitive detection and surveillance in low-transmission settings. In addition, the book discusses epitranscriptomic regulation and genetic determinants of antimalarial drug resistance, integrating molecular mechanisms with parasite adaptation under drug pressure. The final sections address antimalarial drug discovery, emphasizing natural products and modern target-based approaches for the development of new therapeutic agents.Key Features: 1) Examines the molecular mechanisms underlying Plasmodium pathogenesis, host-parasite interactions, and cellular invasion processes2) Explores CRISPR-based genome editing for target validation and functional genomics in malaria research.3) Reviews the latest molecular diagnostics, biosensor platforms, and rapid point-of-care technologies.4) Examines host immunity, immunopathology, and parasite-driven immune evasion mechanisms.5) Discusses drug resistance mechanisms, gene-editing-based target identification, and novel therapeutic strategies.This book is intended for researchers and students of molecular parasitology, immunology, and infectious diseases.

Produktinformation

Utgivningsdatum2026-08-05
Mått156 x 234 x undefined mm
FormatInbunden
SpråkEngelska
Antal sidor232
FörlagTaylor & Francis Ltd
ISBN9781041144731

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Gourab Paul is an Assistant Professor at Amity University, Mohali, with over a decade of research experience in cell and molecular biology. He completed his Ph.D. in Life Sciences from ICGEB, New Delhi, focusing on novel molecular complexes involved in malaria pathogenesis. His research expertise spans protein expression and purification, genetic engineering, Plasmodium biology, and bioinformatics, complemented by postdoctoral training at Weill Cornell Medicine, New York. Dr. Paul has contributed significantly to the understanding of host-parasite interactions, has multiple peer-reviewed publications, and continues to mentor undergraduate and postgraduate students while advancing research in infectious diseases and bioinformatics.Mohammed Tarique is an experienced molecular biologist whose research spans parasitology, infectious diseases, nanomedicine, and drug discovery. He completed his postdoctoral research at Jamia Millia Islamia, New Delhi, supported by the Dr. D.S. Kothari Postdoctoral Fellowship, and received earlier training at the International Centre for Genetic Engineering and Biotechnology (ICGEB), where he worked extensively on malaria biology and molecular parasitology. Dr. Tarique has published widely in international peer-reviewed journals, authored several academic books with Springer Nature and CRC Press, and holds multiple patents related to diagnostic and therapeutic technologies. His work combines molecular insights with translational research aimed at developing new tools for disease diagnosis and management. Alongside his research activities, he serves on the editorial boards of several scientific journals, contributing actively to peer review and academic publishing.

Chapter 1. Molecular Biology of Plasmodium Falciparum. Chapter 2. Genetic Engineering and Functional Genomics in Plasmodium falciparum. Chapter 3. Advances in Malaria Diagnostic Techniques. Chapter 4. Novel Molecular Complexes and Their Roles in RBC Invasion. Chapter 5. Epitranscriptomic Mechanisms of Antimalarial Drug Resistance and RNA-Directed Interventions. Chapter 6. Molecular Basis of Drug Resistance in Plasmodium. Chapter 7. Role of Natural Compounds in Antimalarial Therapy. Chapter 8. Multi-Component Subunit Vaccines Against Plasmodium falciparum.