Neuroscience for Clinicians

Basic Processes, Circuits, Disease Mechanisms, and Therapeutic Implications

Inbunden, Engelska, 2021

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Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets .This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.

Produktinformation

Utgivningsdatum2021-10-07
Mått282 x 226 x 43 mm
Vikt2 427 g
FormatInbunden
SpråkEngelska
Antal sidor832
FörlagOUP USA
ISBN9780190948894
UtmärkelserFinalist, 2022 PROSE Award for Clinical Medicine, The Association of American Publishers

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Preface Section I: Molecular and Cellular MechanismsCh1. Overview: Cellular Components of the Nervous System and Disease MechanismsCh2. Organization of the Cell MembranesCh3. Intracellular SignalingCh4. DNA: Epigenetic Control of Transcription and Repair MechanismsCh5. RNA Metabolism and Control of TranslationCh6. Proteostasis Ch7. Vesicular Trafficking Ch8. CytoskeletonCh9. Axonal Transport Ch10. Axon and MyelinCh11. Mitochondria and Energy MetabolismCh12. Mechanisms of Cell Death and Axonal DegenerationCh13. Growth Factors, Survival, and Regeneration Section II: Excitability, Signal Communication, and Plasticity Ch14. Ion Channels and ChannelopathiesCh15. Principles of Synaptic Transmission and Presynaptic SynaptopahiesCh16. Neurotransmission, Neuromodulation, and PlasticityCh17. Glutamatergic Transmission, Plasticity and SynaptopahiesCh18. Inhibitory Amino Acid Transmission and SynaptopahiesCh19. Cholinergic Transmission Ch20. Monoaminergic Neurotransmission Section III: Microenvironment and Mechanisms of Injury and repairCh21. Astrocyte-Neuron InteractionsCh22. Neuronal MicroenvironmentCh23. Microglia and Inflammation in the Nervous System Section III: Neuronal Interactions in Cortical and Subcortical Circuits Ch24. Neocortical CircuitsCh25. Hippocampal and Amygdala CircuitsCh26. Thalamocortical InteractionsCh27. Sleep Ch28. Behavioral State Control Ch29. Sensory ProcessingCh30. Cortical Motor Control Ch31. Segmental Spinal Motor ControlCh32. Brainstem Motor Control Ch33. CerbellumCh34. Basal ganglia Section V: Homeostatic Systems Ch35. NociceptorsCh36. Central Pain Processing and Modulation Ch37. Autonomic Nervous SystemCh38. Forebrain Control of Homeostasis and Adaptation Section VI: Cortical Networks and Cognitive DomainsCh39. Emotion and Social CognitionCh40. Episodic Memory, Navigation, and Inner Thoughts Ch41. Language, Speech, and Semantic CognitionCh42. Cortical Executive Networks and High-level Behavioral and Cognitive Control