Neurobiology of Alcohol Dependence

Inbunden, Engelska, 2014

AvAntonio Noronha,Changhai Cui,Robert Adron Harris,John C. Crabbe

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Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence.

Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels
Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence
Chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

Produktinformation

Utgivningsdatum2014-05-12
Mått216 x 276 x 32 mm
Vikt1 900 g
FormatInbunden
SpråkEngelska
Antal sidor566
FörlagElsevier Science
ISBN9780124059412

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Missbruk inom Medicin
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Section I: Neurocircuitry of Alcohol Dependence 1. Frameworks of alcohol addiction: Alcohol addiction as a reward deficit and stress surfeit disorder2. Basal ganglia networks and mechanisms of voluntary actions: implications for alcohol addiction and dependence3. Prefrontal limbic striatal circuits and alcohol addiction in humans4. Molecular adaptations in mesolimbic circuitry and pathological ethanol intake5. The bed nucleus of the stria terminalis: A critical site of ethanol-induced alterations in neurotransmission6. Stress and alcohol drinking behavior7. Alcohol and developing neuronal circuits8. Human imaging studies of brain circuitry disrupted by alcoholismSection II: Neurosignaling and Neuroplasticity of Alcohol Dependence 9. From signaling pathways to behavior: The light and dark sides of alcohol10. Glutamate signaling in alcohol abuse and dependence11. Central amygdala neuroplasticity in alcohol dependence 12. Neural plasticity in the ventral tegmental area and alcohol dependence13. Extrasynaptic GABA receptors and alcohol 14. Cannabinoids and the neural actions of alcohol15. Impact of alcohol abuse and dependence on the structure and function of the prefrontal cortex16. Molecular mechanisms underlying the development of functional and behavioral tolerance to alcoholSection III: Gene and Behavior17. Alcohol and the brain: An epigenetic viewpoint18. The genetic complexity of alcohol drinking in rodents19. Alcohol dependence, withdrawal, and relapse20. Insights from non human primates on risks for drinking to dependence21. The potential role of glucocorticoids and the HPA axis in alcohol dependence22. Anxiety and alcohol use disorders: A perspective from molecular and epigenetic studies23. The genetics of alcohol responses of invertebrate model systems24. MicroRNAs in alcohol abuse and toxicity25. Gene and behavior26. Complex genetics of alcoholism