Molecular Biology of Assemblies and Machines

Inbunden, Engelska, 2016

Av Alasdair Steven, Wolfgang Baumeister, Louise N. Johnson, Richard N. Perham, Louise N. (University of Oxford) Johnson

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Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine.Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Produktinformation

Utgivningsdatum2016-02-18
Mått219 x 276 x 34 mm
Vikt1 980 g
FormatInbunden
SpråkEngelska
Antal sidor880
FörlagTaylor & Francis Inc
ISBN9780815341666

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Biologi inom Naturvetenskap och teknik

Wolfgang Baumeister is Director and Head of the Department of Structural Biology at the Max Planck-Institute of Biochemistry in Martinsried, Germany. Baumeister studied biology, chemistry and physics at the Universities of M nster and Bonn and obtained his PhD from the University of D‘sseldorf. In 1973, he began his career as Research Associate in the Department of Biophysics at the University of D‘sseldorf and held a Heisenberg Fellowship spending time at the Cavendish Laboratory in Cambridge, England. In 1982 he became a Group Leader at the Max-Planck-Institute of Biochemistry in Martinsried, Germany and then appointed Director and Head of the Department of Structural Biology. Baumeister pioneered the development of cryo-electron tomography and his work has shaped the understanding of the structure and function of the cellular machinery of protein degradation. His awards include the Otto Warburg Medal, the Schleiden Medal, the Louis-Jeantet Prize for Medicine, the Stein and Moore Award, the Harvey Prize in Science and Technology and the Ernst Schering Prize. He is a member of several academies including the US National Academy of Sciences and the American Academy of Arts and Sciences.Louise N. Johnson was an Emeritus Fellow of the Corpus Christi College at the University of Oxford in Cambridge, UK. Johnson was educated at University College, London, and began her postgraduate career at the Royal Institution working with Lawrence Bragg and David Phillips. There she co-discovered the structure of lysozyme in 1965, then the second protein and first enzyme ever solved by X-ray crystallography. As the David Phillips Professor of Molecular Biophysics at Oxford from 1990 to 2007, Johnson led structural studies of regulatory proteins of the cell cycle, protein kinases, and glycogen metabolism, crucial to understanding the origin of disease and new drug design. In 1976, together with Tom Blundell, she coauthored the widely infl

1. The Machines and Assemblies of Life2. Chromatin3. DNA Replication4. DNA Repair and Recombination5. Transcription6. Protein Synthesis and Folding7. Intracellular Proteolysis: Protein Quality Control and Regulatory Turnover8. Assembly of Viruses9. Multienzyme Complexes: Catalytic Nanomachines10. Transport11. Connectivity and Communication12. Signaling13. The cell cycle and cell death14. Motility15. Bioenergetics16. Membrane Channels and Transporters17. Complexes of the Immune System