Del 1241 i serien Advances in Experimental Medicine and Biology

Mechanisms of Genome Protection and Repair

Häftad, Engelska, 2021

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At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification.

Produktinformation

Utgivningsdatum2021-05-08
Mått178 x 254 x 13 mm
Vikt506 g
FormatHäftad
SpråkEngelska
SerieAdvances in Experimental Medicine and Biology
Antal sidor220
FörlagSpringer Nature Switzerland AG
ISBN9783030412852

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Dmitriy Zharkov is the head of the Novosibirsk State University laboratory of protein engineering. He is a leading specialist in the field of fundamental mechanisms of DNA damage, DNA reparation and cell response to genotoxic stress. He has discovered several ferments of human reparation, defined special structures of some DNA-glycosylases and developed the theory of substrate specificity of ferments that recognize nucleic acids as dynamic multi-stage process.

Preface.- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix–Hairpin–Helix Structural Superfamily.- Protein Engineering of DNA-Dependent Enzymes.- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis.- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA.- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance.- Mystery of Expansion: DNA Metabolism and Unstable Repeats.- The Detection of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health.- Biotransformation and Toxicities of Aristolochic Acids.- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses.- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.