Ligand-Macromolecular Interactions in Drug Discovery

Methods and Protocols

Häftad, Engelska, 2016

AvAna Cecília A. Roque,Ana Cecilia A. Roque,Ana Cecília a. Roque

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In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds, either natural or synthetic, and complementary biological targets, within the scope of drug discovery.

Produktinformation

Utgivningsdatum2016-08-23
Mått193 x 260 x 17 mm
Vikt647 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor297
FörlagHumana Press Inc.
ISBN9781493961771

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Reviews.- An Historical Overview of Drug Discovery.- Ligand Macromolecule Interactions: Theoretical Principles of Molecular Recognition.- X-Ray Crystallography in Drug Discovery.- Virtual Screening of Compound Libraries.- Protocols.- Combinatorial Chemistry and the Synthesis of Compound Libraries.- Ligand-Based Nuclear Magnetic Resonance Screening Techniques.- Isothermal Titration Calorimetry and Differential Scanning Calorimetry.- Adaptive Combinatorial Design of Focused Compound Libraries.- Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors.- Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays.- Small Molecule Protein Interaction Profiling with Functional Protein Microarrays.- Capillary Electrophoresis in Drug Discovery.- SPR in Drug Discovery: Searching Bioactive Compounds in Plant Extracts.- Application of Frontal Affinity Chromatography with Mass Spectrometry (FAC#x2013;MS) for Stereospecific Ligand#x2013;Macromolecule Interaction, Detection and Screening.- GPC Spin Column HPLC#x2013;ESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins.- A Scintillation Proximity Assay for Fatty Acid Amide Hydrolase Compatible with Inhibitor Screening.- A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening.- Ligand#x2013;Macromolecule Interactions in Live Cells by Fluorescence Correlation Spectroscopy.