Jason P. Sheehan is the Vice Chair and Harrison Distinguished Professor of Neurological Surgery at the University of Virginia (UVA). In addition, he is also a Professor of Radiation Oncology and Biomedical Engineering at the University of Virginia. He serves as the Editor-In-Chief of the Journal of Neuro-Oncology and Associate Editor of Neurosurgical Focus. He has held many leadership positions including ones in the American Association of Neurological Surgeons, the AANS/CNS Tumor Section, International Stereotactic Radiosurgery Society, and the International Radiosurgery Research Foundation. He has published more than 800 peer reviewed papers in journals and contributed to and/or edited dozens of books.Daniel M. Trifiletti, M.D, is an international leader in radiation oncology and stereotactic radiosurgery. His research includes numerous clinical studies involving radiation, surgery and drug therapies in the treatment of tumors. Dr. Trifiletti's short-term research goals focus on describing the impact of radiation on the priming of the brain tumor microenvironment. Discovering the biological underpinnings of radiation priming will allow for novel, "game-changing" cancer therapies, rapid translation to early-stage clinical trials and, ultimately, improved outcomes in patients with fatal diseases.Ajay Niranjan, MD, MBA, is a professor of Neurological surgery at the University of Pittsburgh. He is the Director of Radiosurgery Research and associate director of Center of image guided neurosurgery (CIGNS) at University of Pittsburgh Medical Center. In addition, he is the director of UPMC Brain Mapping Center. He serves as the associate editor for the radiosurgery section of Neurosurgery and is the Executive Director of International Radiosurgery Research Foundation (IRRF). He has published more than 350 peer reviewed papers in journals and edited 5 books.