Dr. Maliha Uroos completed her PhD in synthetic organic chemistry in 2012 from the University of Nottingham under HEC Faculty Development Scholarship. She was awarded EPSRC post-doctoral fellowship (2012-13) at the University of Nottingham, UK. She was appointed Lecturer at University of the Punjab in 2007 and currently working as Associate Professor (2020 to date) and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab. Her main focus is synthetic organic chemistry and research interests include synthesis and applications of ionic liquids, synthesis of biologically active molecules, sustainable energy production and development of green processes for setting up bio-refinery from agricultural waste. Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential. Sadia Naz is currently a PhD student at Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab (2018 to onwards) and is working as research assistant in HEC NRPU project with Dr. Maliha Uroos (2019 to onwards). She has publications in international journals and presented her work in various international and national conferences. Her research interests include synthetic organic chemistry, ionic liquids, conversion of agricultural waste materials into valuable platform chemicals. Prof. Muhammad Raza Shah is a professor and Director of the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. He holds four US patents. Dr. Shah has received numerous awards, including the Khwarizmi International Award from the Ministry of Science, Research and Technology, Iran (2023). He has also been honored with the Civil Award Tamgha-i-Imtiaz (2015), Dr. Raziuddin Prize (2015), Prof. Atta-ur-Rahman Gold Medal by the Pakistan Academy of Sciences, Avicenna Science & Innovation Award (2015) by Brain Trust UK, and the Abdus Salam Award in Chemistry (2006). He was named TWAS Young Affiliate in 2010 by The World Academy of Sciences. Prof. Shah is a Fellow of the International Union of Pure and Applied Chemistry, the Chemical Society of Pakistan, the Islamic World Academy of Sciences, and the Royal College of Physicians (Edinburgh). Dr. Shah has conducted 29 Phase-I (BE and PK) studies, 04 Phase-II Randomized Clinical Trial as PI and lead the Phase-I RCT of Sinopharm COVID-19 vaccine and Phase-III RCT of COVID-19 booster vaccine as country PI.

• 1. Indole alkaloids; Spirooxindoles2. Brevianamide A and B3. Citrinadin A and B4. Coerulescine and Horsfiline5. (±)-Elacomine and (±)-Isoelacomine 6. Gelsemine7. Paraherquamide A and B8. Rynchophylline and Isorynchophylline9. Spirotryprostatin A 10. (‒)-Spirotryprostatin B11. Strychnofoline

Dr. Maliha Uroos completed her PhD in synthetic organic chemistry in 2012 from the University of Nottingham under HEC Faculty Development Scholarship. She was awarded EPSRC post-doctoral fellowship (2012-13) at the University of Nottingham, UK. She was appointed Lecturer at University of the Punjab in 2007 and currently working as Associate Professor (2020 to date) and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab. Her main focus is synthetic organic chemistry and research interests include synthesis and applications of ionic liquids, synthesis of biologically active molecules, sustainable energy production and development of green processes for setting up bio-refinery from agricultural waste. Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential. Sadia Naz is currently a PhD student at Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab (2018 to onwards) and is working as research assistant in HEC NRPU project with Dr. Maliha Uroos (2019 to onwards). She has publications in international journals and presented her work in various international and national conferences. Her research interests include synthetic organic chemistry, ionic liquids, conversion of agricultural waste materials into valuable platform chemicals. Prof. Muhammad Raza Shah is a professor and Director of the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. He holds four US patents. Dr. Shah has received numerous awards, including the Khwarizmi International Award from the Ministry of Science, Research and Technology, Iran (2023). He has also been honored with the Civil Award Tamgha-i-Imtiaz (2015), Dr. Raziuddin Prize (2015), Prof. Atta-ur-Rahman Gold Medal by the Pakistan Academy of Sciences, Avicenna Science & Innovation Award (2015) by Brain Trust UK, and the Abdus Salam Award in Chemistry (2006). He was named TWAS Young Affiliate in 2010 by The World Academy of Sciences. Prof. Shah is a Fellow of the International Union of Pure and Applied Chemistry, the Chemical Society of Pakistan, the Islamic World Academy of Sciences, and the Royal College of Physicians (Edinburgh). Dr. Shah has conducted 29 Phase-I (BE and PK) studies, 04 Phase-II Randomized Clinical Trial as PI and lead the Phase-I RCT of Sinopharm COVID-19 vaccine and Phase-III RCT of COVID-19 booster vaccine as country PI.

• 1. Indole alkaloids; Spirooxindoles2. Brevianamide A and B3. Citrinadin A and B4. Coerulescine and Horsfiline5. (±)-Elacomine and (±)-Isoelacomine 6. Gelsemine7. Paraherquamide A and B8. Rynchophylline and Isorynchophylline9. Spirotryprostatin A 10. (‒)-Spirotryprostatin B11. Strychnofoline

Dr. Maliha Uroos completed her PhD in synthetic organic chemistry in 2012 from the University of Nottingham under HEC Faculty Development Scholarship. She was awarded EPSRC post-doctoral fellowship (2012-13) at the University of Nottingham, UK. She was appointed Lecturer at University of the Punjab in 2007 and currently working as Associate Professor (2020 to date) and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab. Her main focus is synthetic organic chemistry and research interests include synthesis and applications of ionic liquids, synthesis of biologically active molecules, sustainable energy production and development of green processes for setting up bio-refinery from agricultural waste. Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential. Sadia Naz is currently a PhD student at Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab (2018 to onwards) and is working as research assistant in HEC NRPU project with Dr. Maliha Uroos (2019 to onwards). She has publications in international journals and presented her work in various international and national conferences. Her research interests include synthetic organic chemistry, ionic liquids, conversion of agricultural waste materials into valuable platform chemicals. Prof. Muhammad Raza Shah is a professor and Director of the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. He holds four US patents. Dr. Shah has received numerous awards, including the Khwarizmi International Award from the Ministry of Science, Research and Technology, Iran (2023). He has also been honored with the Civil Award Tamgha-i-Imtiaz (2015), Dr. Raziuddin Prize (2015), Prof. Atta-ur-Rahman Gold Medal by the Pakistan Academy of Sciences, Avicenna Science & Innovation Award (2015) by Brain Trust UK, and the Abdus Salam Award in Chemistry (2006). He was named TWAS Young Affiliate in 2010 by The World Academy of Sciences. Prof. Shah is a Fellow of the International Union of Pure and Applied Chemistry, the Chemical Society of Pakistan, the Islamic World Academy of Sciences, and the Royal College of Physicians (Edinburgh). Dr. Shah has conducted 29 Phase-I (BE and PK) studies, 04 Phase-II Randomized Clinical Trial as PI and lead the Phase-I RCT of Sinopharm COVID-19 vaccine and Phase-III RCT of COVID-19 booster vaccine as country PI.

• 1. Indole alkaloids; Spirooxindoles2. Brevianamide A and B3. Citrinadin A and B4. Coerulescine and Horsfiline5. (±)-Elacomine and (±)-Isoelacomine 6. Gelsemine7. Paraherquamide A and B8. Rynchophylline and Isorynchophylline9. Spirotryprostatin A 10. (‒)-Spirotryprostatin B11. Strychnofoline