Human Pluripotent Stem Cell Derived Organoid Models

Jason R. Spence, PhD, is an Associate Professor of Internal Medicine, Cell and Developmental Biology and Biomedical Engineering at the University of Michigan Medical School. He attended Canisius College in Buffalo, NY, as an undergraduate. He attended graduate school at Miami University (Ohio) where his research focused on understanding mechanisms that drive regeneration and tissue repair in unique model organisms that maintain regenerative ability throughout life, including Notophthalmus viridescens (Eastern Newt), Ambystoma mexicanum (Axolotl) and the chick. He performed postdoctoral research Cincinnati Children’s Hospital, where he turned his focus to understanding mechanisms that regulate embryonic development of endoderm-derived tissue (pancreas, liver, intestine) and utilized human pluripotent stem cells (hPSCs) to understand human differentiation and development. During this time, he pioneered methods to differentiate 3-dimensional intestinal organoids from human pluripotent stem cells. In 2011, Dr. Spence joined the faculty of the University of Michigan Medical School. The focus of the Spence lab include using 3-dimensional organoid human models to study human development and disease, with research focused on understanding intestinal, lung and esophageal development, homeostasis and disease.

• 1. Pluripotent stem cell derived gastric organoidsYana Zavros2. Pluripotent stem cell derived esophageal organoidsJames Wells3. Pluripotent stem cell derived small intestinal organoidsDavid R. Hill4. Pluripotent stem cell derived colonic organoidsJorge Munera5. Pluripotent stem cell intestinal organoids with an Enteric Nervous SystemMaxime Mahe6. Pluripotent stem cell derived airway organoids Finn Hawkins7. Pluripotent stem cell derived alveolar organoidsShimpei Gotoh8. Pluripotent stem cell derived liver bud organoids Takanori Takebe9. Pluripotent stem cell derived thyroid organoids Sabine Costagliola10. Pluripotent stem cell derived renal organoidsJennifer Harder11. Pluripotent stem cell derived cerebral organoids Gray Camp12. Generating ventral spinal organoids from human induced pluripotent stem cellsShi Yan Ng13. Pluripotent stem cell derived retinal organoidsJason Meyer14. Pluripotent stem cell derived inner ear organoidsEri Hashino15. Pluripotent stem cell derived skinKarl R. Koehler16. Pluripotent stem cell derived cholangiocytes and cholangiocyte OrganoidsAnne Dubart-Kupperschmitt