This book constitutes the revised selected papers of the 14th International Conference on High-Performance Computing Systems and Technologies in Scientific Research, Management and Production Automation, HPCST 2024, held in Barnaul, Russia, during May 17–18, 2024.The 19 full papers included in this book were carefully reviewed and selected from 79 submissions. They are organized into the following topical sections: Hardware for High-Performance Computing and Signal Processing; Information Technologies and Computer Simulation of Physical Phenomena; Computing Technologies in Data Analysis and Decision Making; and Information and Computing Technologies in Automation and Control Science.