Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.Dr. Amarish K Yadav is a postdoctoral research scholar at North Carolina State University. His current research interest is developing gene-drive systems using CRISPR/Cas9 in Drosophila suzukii. After obtaining his master’s degree in biotechnology, he was awarded his Ph.D. from Banaras Hindu University in 2017. He has worked in collaboration with many neuroscientists and researchers to understand the molecular mechanisms of Alzheimer’s and Parkinson’s diseases progression and therapeutics. Dr. Yadav has published his research findings in peer-reviewed journals and has also authored a book chapter on neurodegenerative diseases modeling in drosophila. Dr. Yadav has participated and presented his research work at various national and international conferences and symposia. Dr. Burkhard Poeggeler (Georg-August-University of Göttingen, Germany) holds a PhD in Biochemistry and has authored over 120 PubMed-indexed publications. His research focuses on neuroprotection, redox biology, and regenerative pharmacology. Dr. George Perry, Ph.D. Professor of Biology and Chemistry Semmes Foundation Distinguished University Chair in Neurobiology He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.

• IntroductionBurkhard Poeggeler 1. Therapeutic potential of genome editing tools in neurodegenerative diseasesAnkur Kumar, Nandigam Pardhipa, Sachin G. Swami, Vibha Dwivedi and Anand K. Singh2. Genetic and molecular basis of neurodegenerative diseasesSunanda Yogi, Anjali Sangeeth, Anuradha Venkatakrishnan Chimata, Radhika Padma and Amit Singh3. Genome editing tools: principles, structures, and mechanismsRayees Ahmad Naik, Mehak Naseer Mir, Roshni Rajpoot, Sonalika Singh, Kusum Singh and Sandeep Kumar Singh4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseasesShailendra Kumar Mishra, Hung-Ming Chang, Ahmad A. Obaid and Sandeep Kumar Singh5. Use of CRISPR system in genetic screening to detect neurodegenerative diseaseKoyel Kar6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseasesJosephine Esposto7. Transgene delivery system: viral, nonviral, and other methods for central nervous systemBhupender Sahu, Bibhudendu Behera and Umesh Kumar8. Gene therapies for neurodegenerative disease: current knowledge and challengesBhumi Arora, Sakshi Garg, Aditya Shrivastav, Mrinalini Sharma, Bhupender Sahu and Umesh Kumar9. Gene therapy under clinical trials for neurodegenerative diseasesBhupender Sahu, Lakshita Tyagi, Prshant Tyagi and Umesh Kumar10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeuticsBurkhard Poeggeler