From Globular Proteins to Amyloids

Professor Irena Roterman-Konieczna completed her PhD at the Nicolaus Copernicus Medical Academy Krakow, Poland and undertook her postdoctoral studies at Cornell University, USA. She is the director of the Department of Bioinformatics and Telemedicine at Jagiellonian University – Medical College, Poland. Her fields of interest are protein structure, folding simulation as well as systems biology. She is the author of "Protein Folding in Silico", published by Woodhead Publishing in 2012., and "From Globular Proteins to Amyloids" published by Elsevier in 2020. She is the Chief Editor of the journal Bio-Algorithms and Med-Systems (de Gruyter).

• 1. Description of the fuzzy oil drop model2. Folding with the active participation of water3. Information coded in protein structure4. Gobular or ribbon-like micelle5. Proteins structured as spherical micelles6. Local discordance6. A. The active site in a single-chain enzyme identified as local deficiency of hydrophobicity6. B. Protein-protein interaction encoded as an exposure of hydrophobic residues on the surface6. C. Ligand binding cavity coded in form of local deficiency of hydrophobicity7. Solenoid – amyloid under control8. Composite structures9. Permanent chaperons9. A. Non-amyloid structure of the aβ(1-42) polypeptide requiring a permanent chaperone9. B. Structural properties of aβ(1-42) chain fragments in complex with proteins acting as permanent chaperones10. Amyloids10. A. Amyloid as a ribbon-like micelle10. B. Alternative conformations of the aβ(1-40) amyloid protein10. C. Specificity of amino acid sequence and its role in secondary and super secondary structure generation11. Anti-amyloid drug design12. Predicted structure of the transthyretin amyloid