Evolutionary Dynamics of Malignancy

The Genetic and Environmental Causes of Cancer

Häftad, Engelska, 2024

AvRobert C. Jackson

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For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process.Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells.

Produktinformation

Utgivningsdatum2024-06-26
Mått155 x 235 x 16 mm
Vikt435 g
FormatHäftad
SpråkEngelska
Antal sidor269
Upplaga2023
FörlagSpringer International Publishing AG
ISBN9783031325755

Tillhör följande kategorier

Onkologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Robert C. Jackson provides consulting services in pharmacodynamics and biomathematics. After academic positions at Yale, London, and Indiana Universities he worked in the pharmaceutical and biotechnology industries. Post-retirement volunteer positions have included Chairman of the Discovery Committee and Vice-Chair of the Clinical and Translational Research Committee for the charity, Cancer Research UK. He is author of three previous books and author or co-author of over 150 research papers which have received over 5,000 citations. Recent publications include work on evolutionary biology and on the evolutionary dynamics of leukaemias.

Chapter 1: Cancer as a Disease of Cell Proliferation.- Chapter 2: Genetic and Chromosomal Instability.- Chapter 3:Cancer as a Disease of Defective Cell Cycle Checkpoint Function.- Chapter 4: The DNA Damage Checkpoint.- Chapter 5:Dynamics of the Spindle Assembly Checkpoint.- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance.- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy.- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy.- Chapter 9: The Cancer Stem Cell and Tumour Progression.- Chapter 10: Evading the antitumour immune response.- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention.- Chapter 12: In science, all conclusions are provisional.