Enzyme Chemistry

Impact and applications

Häftad, Engelska, 2011

Av Colin Suckling

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As the first edition of this book was going through the publication process, a revolution was taking place in the technologies available for the study of enzymes. The second edition of 'Enzyme Chemistry, Impact and Applications' takes on board these new develop ments whilst maintaining the overall aims and views of the first edition.

Produktinformation

Utgivningsdatum2011-11-11
Mått155 x 235 x 22 mm
Vikt604 g
FormatHäftad
SpråkEngelska
Antal sidor384
Upplaga2
FörlagSpringer
ISBN9789401073172

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Contributors.- Preface.- 1 Infant Enzyme Chemistry.- 2 The Mechanistic Basis of Enzyme Catalysis.- 2.1 The mechanistic approach.- 2.2 Concepts of catalysis.- 2.3 Describing a mechanism.- 2.4 Kinetics: the measure of catalysis.- 2.5 Stereochemistry and specificity.- 2.6 Stereochemistry and mechanism.- 2.7 Entropy and enzymic catalysis.- 2.8 Acid-base catalysis.- 2.9 Linear free-energy relationships and enzymic reactions.- 2.10 Enzymic efficiency.- 2.11 Examples of intramolecular catalysis.- 2.12 Transition state analogues.- 2.13 Multiple binding sites.- 2.14 Biomimetic chemistry.- 2.15 Conclusion.- References.- 3 Chemical Models of Selected Coenzyme Catalyses.- 3.1 Introduction.- 3.2 Model investigations of nicotinamide coenzymes.- 3.3 Flavin catalyses.- 3.4 Catalyses relating to vitamin B1 and analogues.- 3.5 Pyroxidal catalyses.- 3.6 Catalyses of thiol coenzymes.- 3.7 Conclusion.- References.- 4 Selectivity in Synthesis - Chemicals or Enzymes?.- 4.1 Introduction.- 4.2 Problems overcome.- 4.3 Logic and analogy in the synthetic uses of enzymes and micro-organisms.- 4.4 Enzymes and chemical reagents in ‘competition’.- 4.5 Late-stage functional-group modification.- 4.6 Biomimetic chemistry in synthesis.- 4.7 Enzymes in organic solvents.- 4.8 Advances in protein chemistry and molecular biology.- 4.9 Conclusions.- References.- 5 Enzymes As Targets for Drug Design.- 5.1 Introduction.- 5.2 Case studies in drug discovery.- 5.3 Recent developments and their application to inhibitor design.- References.- 6 The Impact of Metal Ion Chemistry on Our Understanding of Enzymes.- 6.1 Introduction and general chemical principles.- 6.2 The transition elements iron and copper.- 6.3 Transition metal ions.- 6.4 Main group elements.- 6.5 Some toxic metals.- 6.6 Metal ions as drugs.- 6.7Modern physical methods.- 6.8 Conclusions 262 References.- 7 The Enzymology of The Biosynthesis of Natural Products.- 7.1 Introduction.- 7.2 Recent advances in the study of biosynthetic enzymes.- 7.3 Terpenoid cyclases.- 7.4 Problems and prospects 298 References.- 8 Enzymes in The Food Industry.- 8.1 Introduction.- 8.2 Amylases and starch hydrolysis.- 8.3 Enzymes acting on glucose and oligosaccharides.- 8.4 The plant cell wall and its breakdown.- 8.5 Industrial applications of plant cell wall degrading enzymes.- 8.6 Exogenous enzymes in cheese making.- 8.7 Conclusions 348.- References.- 9 Enzymology And Protein Chemistry in The Wider Area of Biology.- 9.1 Introduction.- 9.2 Studies of enzymes by techniques of molecular biology.- 9.3 Theoretical treatments of enzyme catalysis.- 9.4 Protein structure, homology and genetic relationships.- 9.5 Interactions between proteins and DNA.- 9.6 Novel catalysts.- 9.7 Apolipoprotein B.- 9.8 Receptors.- 9.9 Conclusions 372.- References.