Diagnostic Neuropathology

Reflecting the diverse experience and interests of four internationally recognized experts in the field, this clinically oriented resource furnishes a stimulating variety of perspectives on the dynamic field of neuropathology-discussing essential issues such as deriving reasonable differential and final diagnoses from gross and microscopic findings and applying tools of modern molecular and cellular neurobiology to elucidate the pathophysiologic mechanisms of major disease entities commonly encountered in routine neuropathologic practice. A readily accessible guide for the novice and seasoned practitioner seeking a fundamental understanding of neurologic and neuropathologic conditions! Reinforcing concepts and themes of pathophysiology common to many neurologic ailments, Diagnostic Neuropathology describes the appropriate use of ancillary procedures consequential to specific prognoses, including electron microscopy, immunohistochemistry, in situ hybridization, biochemical techniques, molecular probe studies, and microbial cultures integrates molecular and genetic data on metabolic diseases, neoplasms, metabolic abnormalities, and neurodegenerative and malformative conditions with their neuropathologic attributes facilitates clinicopathologic correlation by presenting epidemiologic and clinical information pertinent to particular diseases within a meaningful framework features over 430 lucid photographs of fixed specimens, photomicrographs, and drawings illustrating disease mechanisms and unique cellular responses of the nervous system to injury and more! Invaluably complemented with an excellent bibliography highlighting recent, key literature on various aspects of neuropathology and related neuroscience topics, this practical guide is a requisite for neuropathologists, general and anatomic pathologists, clinical neurologists, neuroradiologists, neurosurgeons, and medical and graduate school students in these disciplines.