Crystallography of Protein Dynamics

Nozomi Ando, PhD, is an Associate Professor of Chemistry and Chemical Biology at the Cornell University. Prof. Ando was born in Denver, CO and grew up in the suburbs of Boston, MA. She received her BS from MIT where she was a physics major and music performance minor. She was drawn to the spaceship-like feel of the Cornell High Energy Synchrotron Source (CHESS) and went to Cornell University for her PhD in physics. As a graduate student in Sol Gruner’s lab, she made her own diamond cells for high-pressure X-ray scattering studies. She then went on to work as a postdoctoral fellow in Cathy Drennan’s lab at MIT, where she developed a fascination with metalloenzymes. In 2014, she was appointed Assistant Professor of Chemistry at Princeton University and started a research program that combines X-ray physics and structural enzymology. In 2018, the Ando lab moved to Cornell University when she joined the faculty in Chemistry & Chemical Biology.

• 1. Introduction to diffuse scattering and data collectionNozomi Ando, Neti Bhatt, Haoyue Wang, Xiaokun Pei and Steve Meisburger2. Processing macromolecular diffuse scattering dataNozomi Ando and Steve Meisburger3. Molecular dynamics (MD) simulations of biological diffuse scatteringDavid Wych and Michael Wall4. Analysis of MD simulations of protein crystalsDavid Wych and Michael Wall5. MD Simulations of macromolecular crystals: Implications for the analysis of diffuse scatteringDavid Case6. Modeling experimental diffuse scattering with non-MD methodsThomas J. Lane, Ariana Peck and Fred Poitevin7. Interpreting Macromolecular Diffraction Through SimulationNicholas K. Sauter and Iris D. Young8. How to refine multiconformer and ensemble models into high resolution multitemperature diffraction dataJames Fraser, Siyuan Du and Daniel Herschlag9. Combining temperature perturbations with X-ray crystallography to study dynamic macromoleculesMichael Thompson10. Room temperature crystallography and X-ray spectroscopy of metalloenzymesJunko Yano11. Pressure perturbation crystallographyEric Girard, Nathalie Colloc’h and Anne-Claire Dhaussy