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This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease.
R. Luke Wiseman Associate ProfessorDepartment of Molecular MedicineThe Scripps Research Institute MEM 220La Jolla, CA 92037, USAPhone: (858) 784-8820Email: wiseman@scripps.eduCole M. HaynesAssociate ProfessorUniversity of Massachusetts Medical SchoolWorcester, MA 01605, USAEmail:Cole.Haynes@umassmed.edu
Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.- Cell Non-Autonomous UPRER Signaling.- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat.- Mitochondria associated membranes and ER stress.- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response.- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling.- ER Protein Quality Control and the Unfolded Protein Response in the Heart.