Combinatorial Synthesis of Natural Product-Based Libraries

Boldi\, Armen M.

• Chemistry on the Interface of Natural Products and Combinatorial Chemistry. Natural Products and Combinatorial Chemistry: An Uneasy Past but a Glorious Future. Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product-Based Compound Libraries. Accessing Expanded Molecular Diversity Through Engineered Biosynthesis of Natural Products. Natural Product-Based Chemically and Functionally Diverse Libraries. The Use of Polymer-Supported Reagents and Scavengers in the Synthesis of Natural Products. Carbohydrate-Derived Small Molecule Libraries. In Search of Novel Antibiotics Using a Natural Products Template Approach. Synthetic Libraries of Fungal Natural Products. Solid-Phase Combinatorial Synthesis Based on Natural Products. Natural Product-Like Combinatorial Libraries Toward the Discovery of Lead Compounds.

"[This book] elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the historical developments to the latest technologies, from the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...A huge amount of references give the readers the opportunity to return to the original papers... ... A large amount of appealing Figures and Schemes illustrate the concepts discussed in the text. The Chapters are well structured... As the authors are from different backgrounds, the book covers various strategies, various synthetic methods, and all types of compound families. ...[A] valuable tool for everybody working in medicinal chemistry as well as the agrochemical, industrial, or academic domains.- François Diederich, Swiss Federal Institute of Technology, Zurich"...Elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ..."- François Diederich, Swiss Federal Institute of Technology, Zurich"A first-rate source of information to learn about different planning strategies"-Victor E. Marquez in Journal of Medicinal Chemistry 2007, Vol. 50, No. 5 (2007)