Colony-Stimulating Factors

Molecular & Cellular Biology, Second Edition,

Inbunden, Engelska, 1997

Av John M. Garland, John M. Garland

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Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

Produktinformation

Utgivningsdatum1997-05-16
Mått178 x 254 x undefined mm
Vikt1 230 g
FormatInbunden
SpråkEngelska
Antal sidor580
Upplaga2
FörlagTaylor & Francis Inc
ISBN9780824794927

Tillhör följande kategorier

Anatomi inom Medicin
Biologi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Overview: introduction to the haematopoietic system; surrogate assays for haematopoietic stem cell activity; receptors for haematopoietic regulators; regulation of the cell cycle by kinases and cyclins; gene organization and regulation; cytokines and apoptosis - the mechanism of regulation of cell death; haematopoietic microenvironments; extracellular matrix- and membrane-bound cytokines; transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor; granulocyte colony-stimulating factor; human interleukin-3 - an overview; macrophage colony-stimulating factor; erythropoietic; the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1; kit-ligand-stem cell factor; interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha; transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth; leukaemia inhibitory factor; interleukin-12 in haematopoiesis; ex vivo expansion of haematopoietic stem and progenitor cells; clinical use of cytokines.

"International Praise for the First Edition. . . . . .a very useful resource book. . .The best chapters are full of insights that will continue to be useful for years to come. "---The Quarterly Review of Biology". . .provide[s] a useful perspective in what is a rapidly moving field. "---Trends in Biochemical Science". . .a remarkable book. . . . . .strongly recommend[ed]. . .It is up to date and contains information and references which everyone working in any aspect of bone marrow biology should have at hand. "---Biologist". . .an excellent compilation of modern knowledge concerning hematopoiesis and the colony-stimulating factors taken from a basic science to a clinical perspective. "---American Journal of Physiology". . .an excellent coverage of the field. "---Hematologic Pathology". . .an exciting volume. "---Cell