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Cd4+cd25+t Cells in Hcv Patients & Prevalence of Bacterial Infection
Mansour Samira R • Abdel-Hai Amal • M Mansour Jihan
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CD4+CD25+Treg lymphocytes are a subset of circulating CD4+T cells with suppressive properties. CD4+CD25+ Treg cells suppress HCV-specific T cell responses. They may play a role in viral persistence. Our study was designed to assess the frequency of Treg cells as well as occurrence of bacterial infection in different clinical presentation of HCV infection in a chosen Egyptian population. Data obtained showed high significant frequency of CD4+CD25+Treg cells in all HCV patients in comparable to healthy individuals. Conversely, within different clinical degrees of HCV infection no significant differences were detected. Higher Frequency of CD4+CD25+ Treg cells detected in HCV patients than in normal individuals may help to be used as a marker for early detection of viral disease and open new area to find a way to disease recovery/protection. The prevalence of bacterial infection among HCV patients was significant high as detected in both blood and urine samples specially among those with late disease episode. Staphylococcus aureus and -hemolytic Streptococcus viridanse were the common infected organisms in blood samples of HCV patients. In urine samples, Escherichia coli was detected.
- Format: Pocket/Paperback
- ISBN: 9783659293467
- Språk: Engelska
- Antal sidor: 160
- Utgivningsdatum: 2012-11-29
- Förlag: LAP Lambert Academic Publishing