Biomarkers and Mental Illness

Paul Guest, PhD has over 25 years of experience in academic and pharmaceutical company environments in designing, carrying out and documenting all aspects of pre-clinical and clinical studies with a focus on psychiatric disorders, metabolic disorders and stem cell therapeutics. He possesses a diverse set of skills in genomic/proteomic areas including immunological, protein-protein interactions, detection technologies, robotics, functional assays and bioinformatic analyses. He has published more than 120 papers in peer-reviewed journals and contributed over 20 chapters to various contributed volumes.

• Part I.- CHAPTER 1 – Psychiatric disorders as “whole body” diseases.- CHAPTER 2 – Treatment of psychiatric disorders: time for a paradigm change?.- CHAPTER 3 – The importance of biomarkers: the required tools of the trade.- Part II.- CHAPTER 4 – Schizophrenia and the mind-body connection.- CHAPTER 5 – Progress for better treatment of depression.- CHAPTER 6 - The special case of bipolar disorder.- CHAPTER 7 – The worrying case of anxiety and stress-related disorders.- CHAPTER 8 - The autism spectrum conditions and the extreme male brain syndrome.- CHAPTER 9 – Gender and psychiatric disorders.- Part III.- CHAPTER 10 – CHAPTER 10 - Biomarkers and new treatments for Alzheimer’s disease.- CHAPTER 11 – Parkinson’s disease, biomarkers and beyond.- Part IV.- CHAPTER 12 – The future: towards personalized medicine.

“This text offers some interesting insights into how and why there has been such a slow understanding of the pathophysiology of mental illness. It sheds light on how complex metabolic and cellular forces as well as brain structures interact. … medical students considering residency in psychiatry would benefit.” (Pollyanna V. Casmar, PsycCRITIQUES, Vol. 62 (14), April, 2017)