Arrestins - Pharmacology and Therapeutic Potential

Inbunden, Engelska, 2013

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This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Produktinformation

Utgivningsdatum2013-12-16
Mått155 x 235 x 30 mm
Vikt846 g
FormatInbunden
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor447
Upplaga2014
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642411984

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.