Anticholestatic effect of Holothuria arenicola extract in rats

Holothuria arenicola is the most important and abundant sea cucumber species in the Mediterranean Sea on the Egyptian coast. The problems associated with antifibrotic drugs are chronic administration, the reduced therapeutic effects and toxicity, so developing antifibrotics from natural products may reduce the risk of toxicity and maintain the therapeutic effectiveness when they used clinically. The therapeutic use of sea cucumbers for healing is established, where they used for joint pain, tendonitis and sprains. The present prospective study correlated the antifibrotic effect of HaE to its direct antioxidant effect that can be related to its contents of phenolic compounds specially chlorogenic acid, pyrogallol, rutin and coumaric acid.