Urocortin effects on gastric motility, emptying and ulceration

Ucn/CRF-R2 system in the upper GI tract ( mainly the stomach plays a completely different role in gastric inflammatory response and motility compared with that of the Ucn/CRF-R1 in the lower GI tract (colon). In the stomach peripheral stimulation of CRFR2 can protect the stomach from stress induced ulceration. Peripheral stimulation of CRFR2 in the stomach inhibits its motility producing gastric stasis. The stimulation of peripheral CRFR2 by specific agonists will be helpful in the treatment of inflammatory condition of the stomach without interfering with colonic functions.