Vetenskap & teknik
Pocket
The Role of P300-Dependent MYC Acetylation in MYC Functions
Vorontchikhina Marina
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Uppskattad leveranstid 7-11 arbetsdagar
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I demonstrate that HAT p300 acetylates MYC preferentially at K157/158 in transfected mammalian cells. I also show that MYC overexpression increases the level of endogenous p300. Moreover, our data provides a potential link between MYC acetylation and its biological functions. I found that MYC acetylation at lysine 158 reduces MYC-activated apoptosis and this could be via transcriptional regulation of pro-apoptotic Nrf1 and Cytochrome c (Cyc) genes. These findings might be important for prospective drug development against MYC-dependent tumors. New therapeutics which drive transformed cells to apoptosis via prevention of MYC acetylation at K157/158 by p300 could be beneficial for the treatment of MYC-dependent cancers.
- Format: Pocket/Paperback
- ISBN: 9783659809163
- Språk: Engelska
- Antal sidor: 188
- Utgivningsdatum: 2015-12-09
- Förlag: LAP Lambert Academic Publishing