Vetenskap & teknik
Pocket
The Effects of Vitamins on DNA and RNA Structures and Dynamics
Heidar-Ali Tajmir-Riahi
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The important role of vitamins is well known with regard to human health and disease. In this book, we review the effects of vitamins, A, B and C on the structure and dynamics of DNA and RNA. The conjugations of vitamin A (retinol and retinoic acid), vitamin B (folic acid) and vitamin C (L-ascorbic acid) by DNA and tRNA were analyzed. The loading efficacies of these vitamins with DNA and RNA were compared in solution. Vitamins bind nucleic acids via hydrophilic, hydrophobic and H-bonding contacts with vitamin C forming more stable DNA and tRNA adducts. The loading efficacies of these vitamins were from 40% to 60%. Vitamins induce major DNA and RNA structural changes, while biopolymers remain in native conformations.
- Format: Pocket/Paperback
- ISBN: 9786131554377
- Språk: Engelska
- Antal sidor: 88
- Utgivningsdatum: 2019-03-05
- Förlag: Editions Universitaires Europeennes