Konst & kultur
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Synthesis and antimicrobial activity of Phthalimide derivatives
Shakir Saleem • Jahangir Alam • Imran Kazmi
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Uppskattad leveranstid 7-11 arbetsdagar
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A series of novel phthalimide derivatives (SV 1-8) have been synthesized and evaluated for antimicrobial activity. The target compounds were prepared by fusion of glycine with phthalic anhydride at 150-155 C to afford 2-(1, 3- dioxoisoindolin-2-yl) acetic acid. The compound 2-(1, 3-dioxoisoindolin-2-yl) acetic acid was treated with thionyl chloride in chloroform to afford 2-(1, 3-dioxoisoindolin-2-yl) acetyl chloride which was further treated with substituted phenols in presence of anhydrous potassium carbonate in dry acetone yielded the final compounds (SV1-8). The structures of the target compounds were characterized on the basis of their m.p., TLC, IR and 1H-NMR data. All the target compounds were evaluated for antibacterial and antifungal activity.
- Format: Pocket/Paperback
- ISBN: 9783845418384
- Språk: Engelska
- Antal sidor: 108
- Utgivningsdatum: 2012-04-22
- Förlag: LAP Lambert Academic Publishing