Vetenskap & teknik
Pocket
Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes
Keyur Pandya
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Uppskattad leveranstid 7-11 arbetsdagar
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Sesquiterpenoid- and steroid-amino acid conjugates demonstrate a broad array of interesting biological properties, as the different segments of the conjugate function collectively to regulate conformation, recognition, transport and solubility. The current project involved developing a facile methodology to synthesize metabolically stable facially amphiphilic conjugates by appending either amino acids (chapter 2) or cationic metal ligand-amino acid complexes (chapter 3) as hydrophilic segments on steroid progesterone and sesquiterpene amorpha-4,11-diene scaffolds. Aminosteroids and C-11 substituted steroids have attracted long lasting interest due to their diverse pharmacological properties. As the stereoselective C- 11 functionalization of a steroid imposes severe steric hindrance due to the C-18 and C-19 angular methyl groups, access to 11-aminoprogesterone is a challenge. Chapter 2 describes stereoselective syntheses of a new family of aminosteroids: 11-aminoprogesterone (11 -NH2-Pro) (76) and its derivatives, including its glycine 77 and L-/D- alanine- 78/79 based conjugates, by nucleophilic substitution or reductive amination.
- Format: Pocket/Paperback
- ISBN: 9786139845354
- Språk: Engelska
- Antal sidor: 280
- Utgivningsdatum: 2019-05-15
- Förlag: LAP Lambert Academic Publishing