Surface-Enhanced Raman Spectroscopy for Cancer Diagnostics

Dr. Linley Li Lin is currently an Assistant Professor at Shanghai Jiao Tong University (SJTU), China. She received her B.S. and Ph.D. degrees from SJTU and worked as a postdoctoral fellow at the University of Illinois at Urbana-Champaign, USA, and SJTU. During her PhD and Postdoctoral research, she was one of the principal researchers of GERTs - a novel SERS nanotag with ultra-high sensitivity, uniformity, and photostability. Her current research interests include deep Raman techniques, surface-enhanced Raman scattering bioimaging, and Raman spectroscopic platform to study biomaterial interfaces. Dr. Seemesh Bhaskar is a Carl R. Woese Institute for Genomic Biology (IGB) fellow at the University of Illinois at Urbana-Champaign (UIUC), USA. He completed his Ph.D. from STAR Lab, Central Research Instruments Facility (CRIF), SSSIHL, and postdoctoral studies from NanoStructured Materials (NSM) group, Indian Institute of Technology (IIT), Bombay. He has pursued research internships at SASTRA University and the Indian Institute of Science, Bangalore, as part of the DST-Inspire program. He is the recipient of the prestigious DST-Inspire scholarship & fellowship, AWSAR, K. V. Rao Scientific Society (KVRSS), Young Achiever, M.Sc. Chemistry Gold medal and All-rounder Gold medal awards. His research work focuses on building effective nano-engineering protocols for photo-plasmonic biosensing at advanced interfaces comprising sustainable bioinspired polymeric hybrids.Dr. Attila Bonyár is an associate professor and head of the Nanotechnology laboratory at the Department of Electronics Technology, Faculty of Electronics Engineering and Informatics, Budapest University of Technology and Economics, Hungary. He has two M.Sc. degrees in electrical engineering (2009) and biomedical engineering (2011), a Ph.D. (2014), and habilitation (2021) in electrical engineering. His current research activities are focused on the development of optical biosensor technologies utilizing plasmonics, low-dimensional nanomaterials, nanocomposites and nanometrology. He was elected to serve in the Hungarian Academy of Sciences (HAS) Electron Devices and Electronics Technology Scientific Committee for two terms (in 2017 and in 2021). He is the chair for IEEE NTC Nanopackaging Technical Committee (since 2022, co-chair since 2020) and actively serves in many other international committees in elected/volunteer positions.Dr. Didier Rouxel is a full Professor at the University of Lorraine, France, and researcher in the Institut Jean Lamour of Nancy, France. He received the Engineer degree from the École Supérieure des Sciences et Techniques de l’Ingénieur de Nancy, in 1989, and the Ph.D. degree in material sciences and engineering from the University of Nancy I in 1993. He was the Leader of the “Micro and NanoSystems” Group of the Institut Jean Lamour, Nancy, France (2013-2018). He was also the Leader of the C’NANO French Grand Est network for the theme “Nanosciences and Materials for Health” (2009-2015), Expert of the European Interreg project NANO4M – Nano For Market, Theme “Nano & Microsensors and Implants (HEALTH)” (2009-2010), Expert from the French national agency ANSES, “Nanomaterials and Health” Working Group (2012-2015). Prof. Rouxel has been involved in the spectroscopic analysis of inorganics and is vastly experienced in the analysis of polymer nanocomposite systems by almost all spectroscopic techniques. His major areas of interest include elastic properties of polymeric materials studied by Brillouin spectroscopy, development of polymer nanocomposite materials, development of micro-devices based on electro-active polymers, piezoelectric nanocrystals, microsensor development for surgery, etc. Since 2011, he has co-directed numerous Franco-Indian collaborative projects. He is Doctor Honoris Causa from Mahatma Gandhi University, Kerala, India (2022).Sabu Thomas is a Professor and Director of the International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala, India. Professor Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields.

• 1. Introduction to Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy (SERS)2. SERS: Relevance, Design Strategies and Applications3. Cancer: relevance of early diagnostics and treatment4. Role of Nanotechnology in Cancer Diagnostics5. Advancement of Nanotechnology in SERS developments: substrates and nanoprobes for label-free and labelled detection6. SERS Immunoassays: Principles and design strategies7. SERS-based imaging and spectroscopic technologies for cancer biomarker detection8. SERS for pathogen detection9. SERS-based Detection of non-invasive Cancer Biomarker: sweat, saliva, sputum, urine, and volatile organic compounds (VOCs)10. SERS-based Detection of invasive Cancer Biomarker: nucleic acids, proteins, lipids, metabolites11. SERS needle patch for skin cancer diagnosis12. SERS-based Multimodal Imaging Techniques13. SERS for intraoperative surgery guidance and tumor boundary detection14. Deep SERS imaging technologies for non-invasive lesion diagnostics15. Artificial Intelligence for SERS: advances in Point-of-Care test analysis16. SERS for cancer diagnostics in clinical samples: Challenges and opportunities17. Emerging Trends in SERS Instrumentation and Signal Enhancement Techniques18. Biocompatibility and Biosafety Considerations in SERS Probe Design19. Tumor detection, Cancer screening, Diagnostics assays20. Concluding remarks: Clinical Translation and Regulatory Considerations of SERS for cancer diagnostics