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Statin Pharmacogenetics in Metabolic Syndrome
Mohammad Misbahuddin • Habib Hamed • Rahman Syed Ziaur
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Metabolic syndrome is a modern era disease which has engulfed wide regions of the world and the problem is increasing at a rapid pace. The atherogenic dyslipidemia associated with the metabolic syndrome predispose to cardiovascular events. The Statins are considered first-line therapy for treating Dyslipidemia. Clinical response to statins is highly variable and genetic factors play an important role. Sterol regulatory element binding factors (SREBF) - SREBF Cleavage Activating Protein (SCAP) pathway play important roles in lipid metabolism and homeostasis. Identification of genes & genetic variants that influence statin responsiveness holds promise for a safe and effective treatment of Dyslipidemia in Metabolic syndrome.
- Format: Pocket/Paperback
- ISBN: 9783838391977
- Språk: Engelska
- Antal sidor: 160
- Utgivningsdatum: 2012-11-30
- Förlag: LAP Lambert Academic Publishing