Shall Herbs Combat Hepatorenal toxicity of Paracetamol?

Paracetamol (acetaminophen) is commonly used pain killer available without prescription in many parts of the world. Alcohol and few drugs increase paracetomol toxicity if consumed together. Accidentally or intentionally taken overdoses of paracetamol may be fatal mainly due to hepatorenal toxicity. Some herbal compounds have been found to reduce paracetamol induced hepatototoxicity; however, kidney is less worked out.In developing countries like India where self medication is common practice, overdoses of paracetamol and additive toxicity due to simultaneous use of herbal drugs exists. Under such circumstances paracetamol toxicity may go unnoticed. Also, general public is not aware of antidotal treatment. Frankly speaking it is not known that commonly used herbal compounds/drugs shall enhance, reduce or nullify paracetamol toxicity. This book describes a serious study on the influence of six commonly used herbal compounds in India on the hepatorenal toxicity of paracetamol in mice.Readers should not try herbals+paracetamol on human beings. Herbal-paracetamol drug like modern synthetic nitroparacetamol (NCX-701) should not be dream.