Semeynaya Giperkholesterinemiya I Ishemicheskaya Bolezn' Serdtsa

Rabota posvyashchena izucheniyu rezul'tatov primeneniya ekstrakorporal'nykh metodov (EM): plazmoobmena (PO), immunofereza lipoproteidov nizkoy plotnosti (LPNP-fereza) i afereza faktora aterogennosti (FA-fereza) u bol'nykh semeynoy giperkholisterinemiey II-a tipa (sGKhS) i ishemicheskoy bolezn'yu serdtsa (IBS). Izucheny pokazaniya k primeneniyu EM, issledovaniya vliyaniya odnokratnykh i mnogokratnykh protsedur PO, LPNP-fereza i FA-fereza na soderzhanie lipidov, lipoproteidov i aterogennye svoystva syvorotok, dana otsenka rezul'tatov primeneniya dlitel'nykh kursov EM i issledovany pobochnye effekty primeneniya etikh metodov u bol'nykh sGKhS i IBS. Patofiziologicheski bolee obosnovannym u bol'nykh sGKhS yavlyaetsya primenenie LPNP-fereza. Naryadu s selektivnym udaleniem aterogennykh lipoproteidov, LPNP-ferez indutsiruet regressiyu uzhe imeyushchikhsya ateroskleroticheskikh izmeneniy i znachitel'no uluchshaet klinicheskoe sostoyanie bol'nykh sGKhS. Na osnove proyavleniya ateroskleroza v kul'ture, pokazano, chto ryad farmakologicheskikh preparatov i antagonisty kal'tsiya obladayut pryamoy antiateroskleroticheskoy aktivnost'yu.