Regeneratsiya Neyronov Spinnomozgovogo Uzla

Travmy perifericheskikh nervov, chasto oslozhnyayushchiesya nevropatiyami, kharakterizuyutsya tyazhelym techeniem, narusheniem dvigatel'noy, chuvstvitel'noy i vegetativnoy funktsiy, soprovozhdayutsya bolevym sindromom. Nesmotrya na shirokoe primenenie khirurgicheskikh podkhodov i fizioterapevticheskikh metodov lecheniya, uroven' invalidizatsii u bol'nykh s povrezhdeniyami perifericheskikh nervov ostaetsya dostatochno vysokim. Intensivnoe nakoplenie faktov po mezhkletochnym vzaimodeystviyam, prirode molekulyarnykh signalov i vnutrikletochnym signal'nym putyam v regeneriruyushchem neyrone sozdaet ratsional'nuyu osnovu dlya poiska effektivnykh farmakologicheskikh stimulyatorov regeneratsii perifericheskogo nerva. V etoy knige na osnovanii dannykh literatury i mnogoletnikh sobstvennykh issledovaniy opisany mekhanizmy posttravmaticheskogo vyzhivaniya i plastichnosti chuvstvitel'nykh neyronov razlichnykh populyatsiy v usloviyakh razreshennogo i zapreshchennogo udlineniya ikh otrostkov, a takzhe mezhkletochnykh vzaimodeystviy v protsesse regeneratsii mezhdu shvannovskimi kletkami i kletkami-satellitami s odnoy storony i chuvstvitel'nymi neyronami s drugoy.