Principles of Stem Cell Biology and Cancer

Future Applications and Therapeutics

Inbunden, Engelska, 2015

1 879 kr

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Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Produktinformation

Utgivningsdatum2015-05-01
Mått175 x 252 x 22 mm
Vikt880 g
FormatInbunden
SpråkEngelska
Antal sidor376
FörlagJohn Wiley and Sons Ltd
ISBN9781118670620

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List of Contributors viiPreface xiiiPart I Stem Cells 11 Isolation and Characterization of Human Embryonic Stem Cells and Future Applications in Tissue Engineering Therapies 3Christian Unger, James Hackland, David Preskey and Harry Moore2 Epigenetics, Stem Cell Pluripotency and Differentiation 27Maria J. Barrero3 Stem Cell Niche and Microenvironment 45Marcio Alvarez-Silva4 Haematopoietic Stem Cells in Therapy 65Jos Domen and Jignesh Dalal5 Isolation and Identification of Neural Stem/Progenitor Cells 85Loic P. Deleyrolle and Brent A. ReynoldsPart II Cancer Stem Cells 1016 The Role of Epithelial–Mesenchymal Transition in Cancer Metastasis 103Paul C. McDonald and Shoukat Dedhar7 Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic Niche 123Fayaz Malik, Hasan Korkaya, Shawn G. Clouthier and Max S. Wicha8 Isolation and Identification of Neural Cancer Stem/Progenitor Cells 145David Bakhshinyan, Maleeha Qazi, Neha Garg, Chitra Venugopal,9 Colon Stem Cells in Colorectal Cancer 169Varun V. Prabhu, Wafik S. El-Deiry and Niklas Finnberg10 Prostate Cancer and Prostate Cancer Stem Cells 193Magdalena E. Buczek, Jerome C. Edwards and Tarik Regad11 Stem Cells and Pancreatic Cancer 213Audrey M. Hendley and Jennifer M. Bailey12 NANOG in Cancer Development 231Bigang Liu and Dean G. Tang13 Liver Cancer Stem Cells and Hepatocarcinogenesis 253Hirohisa Okabe, Hiromitsu Hayashi, Takatsugu Ishimoto, Kosuke Mima, Shigeki Nakagawa, Hideyuki Kuroki, Katsunori Imai, Hidetoshi Nitta, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu and Hideo Baba14 Basic Science of Liver Cancer Stem Cells and Hepatocarcinogenesis 273Katherine S. Koch and Hyam L. Leffert15 Cancer Stem Cell Biomarkers 305Stefano Zapperi and Caterina A.M. La Porta16 Interatomic Analysis of the Stem Cell Marker NANOG in a Prostate Cancer Setting 317Kiran Mall and Graham BallIndex 353