Pharmacology

In this present study, antioxidant potential of the methanol extract of the root of Cajanus cajan Linn (MCCR) was identified by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay, Reducing power assay, total antioxidant activity test and also by total Phenolic content test. In DPPH scavenging assay the IC50 value of the extract was found to be 17.44g/ml while the IC50 value of the reference standard ascorbic acid was 15.06 g/ml.Total antioxidant capacities of MCCR is expressed as the number of equivalent of ascorbic acid 266.7mg/g and the reducing power of MCCR increased with concentration of the sample. The amount of total Phenolic 262.31mg/g Gallic acid. These results suggest that the MCCR providing potent antioxidant properties and offering effective protection from free radicals. Form this view point, MCCR were tested for oral glucose tolerance test (OGTT) in normal mice. The postprandial blood glucose lowering effects of MCCR (400mg/kg) were compared to a known type 2 diabetes drug (Acarbose-50mg/kg). The MCCR were also tested alloxan (120 mg/kg) induced diabetic mice for 7 days.The blood glucose lowering effects MCCR (200mg/kg).