Non-Structural Protein (NS1) Profile of Dengue Patients

Dengue Fever is a mosquito transmitted viral diseases caused by the dengue virus or flavivirus. It is mainly transmitted to humans through the Aedes aegypti and other species of mosquitoes. Many people, especially children and in teens, no signs or symptoms were occur during initial stages of dengue fever. Occurrence of symptoms typically begins after three to fourteen days, when they get bitten from dengue virus causing mosquito. The severe form of dengue fever leads to hemorrhagic fever, causing severe bleeding, low levels of platelets and sudden drop in blood pressure and may also cause sudden death. It increases if the person is infected by second, third or fourth time respectively. DENV (Dengue virus) is an enveloped, single-stranded positive-sense RNA virus. The RNA genome consists of approximately 10,700 nucleotides and encodes with 3,411 amino acids long precursor polyprotein containing three structural proteins (capsid [C], precursor membrane [prM], and envelope [E]) and seven non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). This book provides information on Non-structural 1 (NS1) protein profile of Dengue patients.