Neurotoxic Effect of Occupational pyrethroids pesticides

Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological alterations in the different brain regions are not well known. In this book, we will focus on the effect of BF in the central nervous system using both in vitro and in vivo models to determine whether reactive oxygen species (ROS)-mediated oxidative stress (OS) and neuroinflammation are involved in such alterations. These data suggest that BF induced neurological alterations in different brain regions such as the hippocampus, frontal cortex, and striatum of mice/rats and that this may be associated with neuroinflammation and oxidative stress via the activation of Nrf2/NF-kBp65 pathways, which might promote neurological disorders.