Neopioidnaya Retseptsiya Beta-Endorfina V Rannem Razvitii Mlekopitayushchikh

Dannaya rabota posvyashchena rassmotreniyu roli opioidnogo neyropeptida beta-endorfina, a takzhe ego sinteticheskikh fragmentov, obladayushchikh neopioidnoy aktivnost'yu, v rannem razvitie embrionov myshi. Razobrany effekty vliyaniya beta-endorfina, pentarfina i tsiklopentarfina na protsess formirovaniya blastotsist v usloviyakh in vitro. Pokazana opredelyayushchaya rol' neopioidnykh retseptorov beta-endorfina pri razvitii embrionov v usloviyakh in vivo. Opisany osnovnye puti peredachi vnutrikletochnogo signala pri aktivatsii neopioidnykh retseptorov beta-endorfina. Pokazano vozmozhnoe reguliruyushchee deystvie beta-endorfina i ego sinteticheskikh fragmentov na snizhenie apoptoticheskikh faktorov v protsesse formirovaniya embrionov.