Vetenskap & teknik
Pocket
Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli
Krishna Prakash • Ajeet Kumar
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Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.
- Format: Pocket/Paperback
- ISBN: 9786139861019
- Språk: Engelska
- Antal sidor: 116
- Utgivningsdatum: 2018-06-20
- Förlag: LAP Lambert Academic Publishing