Molekulyarnye Mekhanizmy Stressa

Mnogoletnie issledovaniya transportnykh AT-Faz (Na, K-ATFaza i Sa-ATFaza) tselykh eritrotsitov i molekulyarnoy organizatsii ikh preparatov (teney) u raznykh predstaviteley bez"yadernykh- mlekopitayushchikh i yadernoy ryby pozvolyayut sformulirovat' sleduyushchie printsipy otnositel'no kletochnoy regulyatsii aktivnosti fermentov v norme i pri stressakh. Tsitoplazmaticheskie uchastki AT-Faz soderzhat aktivnye tsentry (ATs) fermentov, stericheski nakhodyashchiesya v tesnom kontakte s belkami membrannogo skeleta, kotoryy s odnoy storony yavlyaetsya bar'erom, otdelyayushchim energeticheskiy blok (fermenty glikoliticheskogo kompleksa), oposreduyut moduliruyushchee vliyanie ATF i Sa2+ v rabote fermentov. S drugoy storony spektrin-aktinovyy ansambl' vypolnyaet rol' depo ATF dlya modulirushchego vliyaniya ATF i obrashchennoy fosfoglitseraznoy i Na, K-ATFaznoy reaktsiy. Membrannyy tsitoskelet otnositel'no tochno orientiruet ATF i aktivnyy tsentr i v to zhe vremya, yavlyaetsya aktseptorom dlya Fn obrazuyushchegosya v khode reaktsii. Izmenenie sootnosheniy ionov v Na, K-ATFaze yavlyaetsya molekulyarnym regulyatorom raboty transportnykh ATFaz v organizme.