Molecular Optimization of Calcineurin Inhibitors for Prion Disease 1

Vetenskap & teknik

Molecular Optimization of Calcineurin Inhibitors for Prion Disease

Saumya Patel • S Prasanth Kumar • Yogesh T Jasrai

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80 sidor
2012

This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.

Författare: Saumya Patel, S Prasanth Kumar, Yogesh T Jasrai
Format: Pocket/Paperback
ISBN: 9783659158957
Språk: Engelska
Antal sidor: 80
Utgivningsdatum: 2012-06-16
Förlag: LAP Lambert Academic Publishing