Metallomics

Bernhard Michalke is leader of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Center Munich - German Research Center for Environmental Health. Since 1996 he has been lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, where he received his habilitation in analytical chemistry in 1999. Since 1988, he is principal researcher at the Helmholtz Center Munich. His reasearch interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neuro-degenerative elements such as manganese and species related neuro-toxic effects in the central nervous system. He has published more than 170 peer reviewed articles and 10 book chapters. Since 1998, he has been co-organizer of several international conferences.

• List of Contributors XVIIPreface XXVPart I Analytical Methods and Strategies in Metallomics 11 The Position of Metallomics Within Other Omics Fields 3Dirk Schaumlöffel1.1 Introduction 31.2 Metallome and Metallomics in Relation to Other “-Ome” and “-Omics” Fields 31.3 Is Metallomics Feasible as a Global Study of the Metallome 71.4 Approaching the Metallome: Study of Metallome Subgroups 81.5 Analytical Strategies in Metallomics 81.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals 101.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup 111.8 Concluding Remarks 14References 152 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques 17Daniel Pröfrock2.1 Introduction 172.2 Analytical Techniques for Metallomics 192.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 302.4 Overview about Coupling Techniques 482.5 Final Remarks and Outlook 58References 583 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis 69Heidi G. Infante3.1 Introduction 693.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation 703.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species 72References 814 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF 83Dirk Schaumlöffel, Robert Hutchinson, Julien Malherbe, Philippe Le Coustumer, Etienne Gontier, and Marie-Pierre Isaure4.1 Introduction 834.2 Bioimaging by LA-ICP-MS 844.3 Bioimaging by NanoSIMS 904.4 Bioimaging by TEM/X-EDS 934.5 Bioimaging by SXRF 1044.6 Conclusions and Outlook 108References 1095 Electrochemistry Coupled toMass Spectrometry for Investigating Oxidative Metabolism of Pt-Based Drug Conjugates: A Novel Approach 117Günther Weber5.1 Introduction 1175.2 EC-MS Methodology 1195.3 EC-MS of Thiols 1195.4 Influence of Cisplatin on Thiol Oxidation 1215.5 Conclusions 125References 126Part II Metallomics in Environment and Nutrition 1296 Selenium and Selenium Species 1316.1 Speciation Analysis Especially of Tin and Selenium in Environmental Matrices 131Maria Ochsenkühn-Petropoulou and Fotios TsopelasReferences 1436.2 Selenium Species Extraction and Speciation in Plants and Yeast 151Lena Ruzik, Katarzyna Bier³a, and Joanna SzpunarReferences 1697 Arsenic and As Species 1737.1 Arsenic Species in Marine Food 173María Carmen Barciela-Alonso and Pilar Bermejo-BarreraReferences 1987.2 Compounds with As–S Bonds: Analytical and Biogeochemical Reasons Why These Species have been Elusive in Biota and Environment 202Jörg Feldmann, Andrea Raab, Helle R. Hansen, Katharina Bluemlein, and Dirk WallschlägerReferences 2187.3 Arsenolipids: An overview of current analytical aspects 222Michael Stiboller, Ronald A. Glabonjat, Georg Raber, Kenneth B. Jensen, and Kevin A. FrancesconiReferences 2348 Analytical Procedures for Speciation of Chromium, Aluminum, and Tin in Environmental and Biological Samples 237Radmila Milâcîc, Tea Zuliani, Janja Vidmar, and Janez Šcancar8.1 Speciation of Chromium 2378.2 Speciation of Aluminum 2508.3 Speciation of Tin 260References 2759 Mercury Toxicity and Speciation Analysis 285Eva M. Krupp, Zuzana Gajdosechova, Tanja Schwerdtle, and Hanna Lohren9.1 Mercury Toxicity 2859.2 Mercury Speciation Analysis 291References 29810 Environmental Speciation of Platinum Emissions from Chemotherapy 305Marianna Vitkova, Gunda Koellensperger, and Stephan Hann10.1 Introduction 30510.2 Elemental Analysis of Platinum 30610.3 Quantification Strategies 30910.4 Preparation of Samples for Total Platinum Analysis by ICP-MS 30910.5 Analysis of Platinum 31010.6 Speciation of Platinum Emissions from Chemotherapy 31110.7 Speciation Strategies for the Determination of CPC 31210.8 Selected Applications 31210.9 Conclusion 314References 31511 Nanoparticles in Environment and Health Effect 319Gaëtane Lespes11.1 Introduction 31911.2 Nanoparticle Overview 31911.3 Analytical Strategies 32611.4 Conclusion 334References 335Part III Metallomics in Medicine and Biology 33912 Metalloproteins 341Maria Montes-Bayón and Elisa Blanco-González12.1 General Introduction to Metalloprotein Analysis 34112.2 Sample Preparation Methodologies to Preserve Metal–Protein Interactions 34212.3 Analytical Strategies for Identification of Metalloproteins 34412.4 Quantitative Strategies for the Analysis of Metalloproteins 349References 35513 Biomedical and Pharmaceutical Applications 35913.1 Selenium and Selenoproteins in Human Health and Diseases 359Jordan Sonet, Anne-Laure Bulteau, and Laurent ChavatteAcknowledgments 370References 37013.2 Metal Species as Biomarkers for Medical Diagnosis: A Case Study of Alzheimer’s Disease 375Tamara García-Barrera, José Luis Gómez-Ariza, and Belén Callejón-LeblicReferences 38513.3 Vanadium Speciation as a Means in Drug Development and Monitoring for Diabetes 388Volker NischwitzReferences 39813.4 Analysis of Pt- and Ru-Based Anticancer Drugs: New Developments 401Sarah Theiner, Luis Galvez, Gunda Koellensperger, and Bernhard K. KepplerReferences 41613.5 Silver Distribution in Skin duringWound Healing 420Marco Roman and Carlo BarbanteReferences 43613.6 Neurodegeneration with Focus on Manganese and Iron Speciation 442Katharina Neth, Julia Bornhorst, and Bernhard MichalkeReferences 457Index 463

"This book covers a comprehensive and broad range of relevant topics in the field of Metallomics with an intended focus on analytical techniques and speciation methods, alone with the corresponding discussion on biometal(loid) sciences. Not only the scientists who are engaging in Metallomics study but also newcomers who want to do research on Metallomics will benefit from reading this book" Qiuquan Wang on behalf of Springer, 31/07/2017