Manual of Neonatal Respiratory Care

Steven M. Donn, MD, FAAP, FAARCProfessor Emeritus of PediatricsDivision of Neonatal-Perinatal MedicineC.S. Mott Children’s HospitalMichigan MedicineUniversity of MichiganAnn Arbor, MIUSAMark C. Mammel, MD, FAAPProfessor of PediatricsUniversity of MinnesotaMinneapolis, MNUSAAnton H.L.C. Van Kaam, MD, PhDProfessor of PediatricsDepartment of NeonatologyEmma Children’s HospitalAmsterdamNetherlandsDr. Donn is actively involved in teaching, research, and patient care activities. He is a member of numerous professional societies, including elected memberships in the Society for Pediatric Research, the European Society for Pediatric Research, and the American Pediatric Society. He is a Fellow of the American Academy of Pediatrics and chaired its national Committee on Medical Liability and Risk Management, and was named a fellow of the american association forrespiratory care for his notable contributions to the field. He has been chosen as one of the “Best Doctors in America” since 1994, and was selected by Child Magazine in 2001 as one of “Ten Pediatricians Who Make a Difference.” He is internationally known for his expertise in the management of respiratory failure in newborns. He has authored more than 250 medical journal articles, edited 34 books and specialty journals, written 250 book chapters, and has produced numerous educational materials on neonatal respiratory complications, hypoxic-ischemic brain injury, and high-technology respiratory support of the newborn. Dr. Donn has been invited internationally to present his research and to teach neonatal intensive care. During his career he has held consulting positions for numerous medical device manufacturers, pharmaceutical companies, and a healthcare management corporation and served on the FDA Specialty Panel for Respiratory and Anesthesia Devices.Dr. Mammel is currently Professor of Pediatrics at the University of Minnesota, after retiring from clinical practice at Children's Hospitals & Clinics of Minnesota in St Paul. He continues to write, serves as a manuscript reviewer for many journals, and is a member of a number of professional societies, including the Society for Pediatric Research, the American Pediatric Society, and is a fellow of the American Academy of Pediatrics. He has also served as a consultant to the NIH. His career passion has been respiratory care of the newborn infant, and he was a pioneer in the development and study of high frequency ventilation. He was also an early proponent and researcher into the use of neonatal pulmonary graphics and measured lung mechanics to optimize the use of the mechanical ventilator. He has been an international speaker, and has published over 250 scientific papers, book chapters, and abstracts.Anton van Kaam is currently professor of neonatology and the chief of the neonatalintensive care units at the Emma Children’s Hospital in the Academic Medical Center and the VU university medical center in Amsterdam, The Netherlands. He did his medical and pediatric training in Rotterdam at, respectively, the Erasmus Medical Center and the Sophia Children’s Hospital. Following his certification in 1997 he moved to the Emma Children’s Hospital in Amsterdam, where he did is training in Neonatology until 1999. Since then, he has been working as a consultant in Neonatology and obtained his PhD degree in 2004.In 2010 he was appointed chief of neonatology at the Emma Children’s Hospital AMC and, in addition, in 2017 at the VU university medical center. In 2014 he was appointed as full professor of neonatology.

• Development of the Respiratory System.- Malformations, Deformations, and Disorders of the Neonatal Airway.- Developmental Lung Anomalies.- Spontaneous Breathing.- Pulmonary Gas Exchange.- Oxygen Therapy.- Oxygen Toxicity.- Pulmonary Mechanics.- Basic Principles of Mechanical Ventilation.- Classification of Mechanical Ventilation Devices.- Ventilator Parameters.- Respiratory Gas Conditioning and Humidification.- Cardio-Respiratory Examination.- Neonatal Resuscitation.- Laryngoscopy and Endotracheal Intubation.- Vascular Access.- Tracheostomy.-  Continuous Monitoring Techniques.- Clinical Controversies in Pulse Oximetry.- Interpretation of Neonatal Blood Gases.- Volumetric Capnography.- Neonatal Pulmonary Graphics.- Radiography.- Transillumination.- Echocardiography.- Bronchoscopy.- Nasal Interfaces for Noninvasive Ventilation.- Humidified High-Flow Nasal Cannula Therapy.- Continuous Distending Pressure.- Sustained Inflation.- Noninvasive Ventilation.- Nasal Intermittent Positive Pressure Ventilation.- Vapotherm High-Flow Support.- Intermittent Mandatory Ventilation.- Synchronized Intermittent Mandatory Ventilaton.- Assist/Control Ventilation.- Pressure Support Ventilation.- Volume-Targeted Ventilation.- Volume Guarantee Ventilation.- Pressure Control Ventilation.- High-Frequency Ventilation: General Concepts.- High-Frequency Jet Ventilation.- High-Frequency Oscillatory Ventilation.- Ventilator Mode Classification.- VIP BIRD Gold Ventilator.- AVEA Ventilator.- Twinstream Ventilator.- Puritan Bennett 840 and 980 Ventilators.- Draeger VN500 Ventilator.- Servo-i Ventilator/NAVA.- SLE 5000 and SLE 4000 Infant Ventilators.- STEPHANIE and SOPHIE Ventilators.- Leoni Plus Infant Ventilator.- Bunnell Life-Pulse High-Frequency Jet Ventilator.- High-Frequency Oscillatory Ventilators.- Hemodynamic Support.- Nutritional Support of Ventilated Infants.- Surfactant Replacement Therapy.- Pharmacologic Agents.- Automatic Control of Oxygen Delivery.- Aerosolization and Nebulization.- Sedation and Analgesia.- Inhaled Nitric Oxide Therapy.- Extracorporeal Membrane Oxygenation.- Liquid Ventilation for Neonatal Respiratory Failure.- Mechanisms of Respiratory Failure.- Tissue Hypoxia.- Indications for Mechanical Ventilation.- Respiratory Distress Syndrome.- Pneumonia.- Meconium Aspiration Syndrome.- Persistent Pulmonary Hypertension of the Newborn.- Congenital Diaphragmatic Hernia.- Pulmonary Hypoplasia/Agenesis.- Chylothorax.- Apnea, Bradycardia, and Desaturation.- Optimizing Lung Volume.- Weaning and Extubation.- Etiology and Pathogenesis.- Management.- Long-Term Outcome of Newborns with Bronchopulmonary Dysplasia.- Thoracic Air Leaks.- Patent Ductus Arteriosus.- Neonatal Pulmonary Hemorrhage.- Retinopathy of Prematurity.- Neurologic Complications of Mechanical Ventilation.- Nursing Care of the Ventilated Infant.- Transport of Ventilated Babies.- Role of the Respiratory Therapist in the NICU.- Long Term Ventilator Dependency in Infants without Lung Disease.- Home Ventilation.- Discharge Planning and Follow-Up of the NICU Graduate.- Initiation of Life Support at the Border of Viability.- Withdrawal of Ventilatory Support.-  Medical Liability, Documentation, and Risk Management.- Interpreting Medical Literature.- Data Collection and Assessment of Respiratory Outcomes.- Practical Quality Improvement in the NICU.- Contemporary Classics in Neonatal Respiratory Care.- Ventilatory Cases.